Brodin L, Christenson J, Grillner S
Neurosci Lett. 1987 Mar 20;75(1):75-9. doi: 10.1016/0304-3940(87)90078-4.
The effects of excitatory amino acid (EAA) antagonists were tested on sensory afferent excitation in the lamprey spinal cord. Paired intracellular recordings were made from mechanosensory neurons (dorsal cells) and second order sensory neurons (giant interneurons). Stimulation of individual dorsal cells evoked mono- and/or polysynaptic excitatory postsynaptic potentials (EPSPs) in giant interneurons. These EPSPs were depressed by the EAA antagonists cis-2,3-piperidine dicarboxylate and kynurenic acid. Small components of the synaptic potentials were due to electrical coupling since they were not depressed by EAA antagonists or by calcium-free solution. The N-methyl-D-aspartate antagonist 2-amino-5-phosphonovalerate did not depress short-latency EPSPs. Thus, mechanosensory neurons in the lamprey spinal cord activate EAA receptors (kainate/quisqualate receptors) on interneurons, via mixed chemical and electrical synapses.
在七鳃鳗脊髓中测试了兴奋性氨基酸（EAA）拮抗剂对感觉传入兴奋的影响。从机械感觉神经元（背侧细胞）和二级感觉神经元（巨大中间神经元）进行细胞内配对记录。刺激单个背侧细胞在巨大中间神经元中诱发单突触和/或多突触兴奋性突触后电位（EPSP）。这些EPSP被EAA拮抗剂顺式-2,3-哌啶二羧酸和犬尿喹啉酸抑制。突触电位的小成分是由于电耦合，因为它们不受EAA拮抗剂或无钙溶液的抑制。N-甲基-D-天冬氨酸拮抗剂2-氨基-5-磷酸戊酸不抑制短潜伏期EPSP。因此，七鳃鳗脊髓中的机械感觉神经元通过混合化学和电突触激活中间神经元上的EAA受体（海人藻酸/quisqualate受体）。
