所有口蹄疫病毒血清型均在两个不同的AUG处起始蛋白质合成。
All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs.
作者信息
Sangar D V, Newton S E, Rowlands D J, Clarke B E
出版信息
Nucleic Acids Res. 1987 Apr 24;15(8):3305-15. doi: 10.1093/nar/15.8.3305.
Abstract
Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used is the concentration of Mg2+.
摘要
口蹄疫病毒基因组在体外和体内的翻译表明，所有七个血清型均在两个不同的AUG处起始蛋白质合成。对这些AUG周围区域的序列分析表明，起始AUG被识别的效率取决于侧翼核苷酸。然而，在体外，决定使用哪个AUG的主要因素是Mg2+的浓度。
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