Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
J Allergy Clin Immunol. 2019 Feb;143(2):797-799.e2. doi: 10.1016/j.jaci.2018.10.005. Epub 2018 Oct 16.
This case demonstrates the essential contribution of the p110δ catalytic 21 domain in adaptive immunity function in a patient with expression of a kinase-dead p110δ mutant.
本病例展示了表达激酶失活 p110δ 突变体的患者中 p110δ 催化 21 结构域在适应性免疫功能中的重要贡献。