National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Department of Biology, University of Missouri, St. Louis, MO 63121, USA; Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.
Mol Plant. 2018 Nov 5;11(11):1328-1343. doi: 10.1016/j.molp.2018.10.001. Epub 2018 Oct 15.
Plant sphingolipids are not only structural components of the plasma membrane and other endomembrane systems but also act as signaling molecules during biotic and abiotic stresses. However, the roles of sphingolipids in plant signal transduction in response to environmental cues are yet to be investigated in detail. In this review, we discuss the signaling roles of sphingolipid metabolites with a focus on plant sphingolipids. We also mention some microbial sphingolipids that initiate signals during their interaction with plants, because of the limited literatures on their plant analogs. The equilibrium of nonphosphorylated and phosphorylated sphingolipid species determine the destiny of plant cells, whereas molecular connections among the enzymes responsible for this equilibrium in a coordinated signaling network are poorly understood. A mechanistic link between the phytohormone-sphingolipid interplay has also not yet been fully understood and many key participants involved in this complex interaction operating under stress conditions await to be identified. Future research is needed to fill these gaps and to better understand the signal pathways of plant sphingolipids and their interplay with other signals in response to environmental stresses.
植物神经酰胺不仅是质膜和其他内膜系统的结构组成部分，而且在生物和非生物胁迫下作为信号分子发挥作用。然而，植物在响应环境信号时，神经酰胺在信号转导中的作用仍有待详细研究。在这篇综述中，我们讨论了神经酰胺代谢物的信号作用，重点是植物神经酰胺。我们还提到了一些微生物神经酰胺，因为关于它们的植物类似物的文献有限，所以在它们与植物相互作用时会引发信号。非磷酸化和磷酸化神经酰胺种类的平衡决定了植物细胞的命运，而负责这种平衡的酶之间在协调的信号网络中的分子连接还不太清楚。植物激素-神经酰胺相互作用之间的机制联系也尚未完全理解，许多在应激条件下参与这一复杂相互作用的关键参与者有待确定。需要开展未来的研究来填补这些空白，更好地理解植物神经酰胺的信号通路及其与其他信号在响应环境胁迫时的相互作用。
