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产碳青霉烯酶:肺炎和菌血症的罕见病因。

Carbapenemase-Producing : A Rare Cause of Pneumonia and Bacteremia.

作者信息

Gonzales Zamora Jose Armando, Corzo-Pedroza Monica, Romero Alvarez Maria, Martinez Octavio V

机构信息

Division of Infectious Diseases, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Department of Pathology and Microbiology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

出版信息

Diseases. 2018 Oct 17;6(4):94. doi: 10.3390/diseases6040094.

Abstract

is a gram-negative bacterium of the family that is usually found in soil, plant and aquatic environments. It is an uncommon human pathogen and has been associated with cases of bacteremia, pneumonia, urinary tract infections, among others. Here, we present the case of an 85-year-old female that developed nosocomial pneumonia and bacteremia caused by . Pertinent microbiological studies detected carbapenemase production codified by the bla gene. The patient was successfully treated with ceftazidime/avibactam and polymyxin. Our case illustrates the pathogenic potential of this organism and highlights the importance of phenotypic and genotypic assays for the appropriate identification of carbapenemase production.

摘要

是该菌科的一种革兰氏阴性菌,通常存在于土壤、植物和水生环境中。它是一种不常见的人类病原体,与菌血症、肺炎、尿路感染等病例有关。在此,我们报告一例85岁女性发生医院获得性肺炎和由引起的菌血症的病例。相关微生物学研究检测到由bla基因编码的碳青霉烯酶产生。该患者接受头孢他啶/阿维巴坦和多粘菌素治疗成功。我们的病例说明了这种生物体的致病潜力,并强调了表型和基因型检测对于正确鉴定碳青霉烯酶产生的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7cb/6313724/f758ca43de0e/diseases-06-00094-g001a.jpg

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