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阿尔茨海默病。

Alzheimer Disease.

机构信息

Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA.

Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA; Research and Development Service, VA Medical Center, St Louis, MO, USA.

出版信息

Clin Geriatr Med. 2018 Nov;34(4):591-601. doi: 10.1016/j.cger.2018.06.006. Epub 2018 Aug 21.

DOI:10.1016/j.cger.2018.06.006
PMID:30336989
Abstract

Alzheimer disease is due to increased amyloid-β coupled with low progranulin. Several brain imaging techniques are helpful in the diagnosis. Drugs available for treating Alzheimer disease have limited clinical utility. Cognitive stimulation therapy is an effective therapy for persons with moderate Alzheimer disease.

摘要

阿尔茨海默病是由于淀粉样蛋白-β增加和颗粒蛋白前体减少引起的。几种脑影像学技术有助于诊断。用于治疗阿尔茨海默病的药物临床疗效有限。认知刺激疗法是治疗中度阿尔茨海默病患者的有效方法。

相似文献

1
Alzheimer Disease.阿尔茨海默病。
Clin Geriatr Med. 2018 Nov;34(4):591-601. doi: 10.1016/j.cger.2018.06.006. Epub 2018 Aug 21.
2
Identifying cost-effective predictive rules of amyloid-β level by integrating neuropsychological tests and plasma-based markers.通过整合神经心理学测试和基于血浆的标志物来识别具有成本效益的淀粉样β蛋白水平预测规则。
J Alzheimers Dis. 2015;43(4):1261-70. doi: 10.3233/JAD-140705.
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Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease.淀粉样蛋白对从临床前阿尔茨海默病到临床阿尔茨海默病的记忆和非记忆下降的影响。
Brain. 2014 Jan;137(Pt 1):221-31. doi: 10.1093/brain/awt286. Epub 2013 Oct 30.
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Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease.高 Aβ 淀粉样蛋白对轻度认知障碍和健康老年人认知的影响：对阿尔茨海默病早期检测的启示。
Neuropsychology. 2013 May;27(3):322-332. doi: 10.1037/a0032321.
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Biomarkers, ketone bodies, and the prevention of Alzheimer's disease.生物标志物、酮体与阿尔茨海默病的预防。
Metabolism. 2015 Mar;64(3 Suppl 1):S51-7. doi: 10.1016/j.metabol.2014.10.033. Epub 2014 Oct 30.
6
β-Amyloidosis and neurodegeneration in Alzheimer disease: who's on first?阿尔茨海默病中的β淀粉样变性与神经退行性变：谁先出现？
Neurology. 2014 May 20;82(20):1756-7. doi: 10.1212/WNL.0000000000000438. Epub 2014 Apr 18.
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Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study.认知和神经影像学特征以及阿尔茨海默病风险个体的脑β-淀粉样蛋白（INSIGHT-preAD）：一项纵向观察性研究。
Lancet Neurol. 2018 Apr;17(4):335-346. doi: 10.1016/S1474-4422(18)30029-2. Epub 2018 Feb 27.
8
Understanding the role of progranulin in Alzheimer's disease.了解颗粒蛋白前体在阿尔茨海默病中的作用。
Nat Med. 2014 Oct;20(10):1099-100. doi: 10.1038/nm.3712.
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What's next for Alzheimer treatment?: while Aβ isn't out of the picture yet, several other therapeutic routes are being explored.阿尔茨海默病治疗的下一步是什么？：虽然β淀粉样蛋白（Aβ）仍未被排除，但目前正在探索其他几种治疗途径。
Ann Neurol. 2013 Apr;73(4):A7-9. doi: 10.1002/ana.23900.
10
Synergistic interaction between amyloid and tau predicts the progression to dementia.淀粉样蛋白和 tau 之间的协同作用可预测向痴呆的进展。
Alzheimers Dement. 2017 Jun;13(6):644-653. doi: 10.1016/j.jalz.2016.11.005. Epub 2016 Dec 23.

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