[胃黏膜相关淋巴组织淋巴瘤放射治疗的回顾性研究结果]
[Results of a retrospective study on radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma].
作者信息
Ghorbal L, Hdiji A, Ben Salah H, Elloumi F, Frikha M, Elloumi M, Daoud J
机构信息
Service de radiothérapie carcinologique, CHU Habib-Bourguiba, avenue Majida-Boulila, 3027 Sfax, Tunisie.
Service de radiothérapie carcinologique, CHU Habib-Bourguiba, avenue Majida-Boulila, 3027 Sfax, Tunisie.
出版信息
Cancer Radiother. 2018 Dec;22(8):763-766. doi: 10.1016/j.canrad.2018.02.001. Epub 2018 Oct 15.
PURPOSE
We aimed to evaluate therapeutic results of radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphomas.
PATIENTS AND METHODS
We reviewed retrospectively the records of 11 patients presenting with gastric MALT lymphoma treated between 1993 and 2014. Patients with low-grade lymphoma in failure after helicobacter eradication had exclusive gastric external radiotherapy. Chemotherapy followed by radiotherapy were indicated in case of high grade lymphoma. Radiotherapy doses range between 30 and 40Gy (2Gy per fraction, five fractions per week).
RESULTS
All tumours were IE stage. Seven patients with low-grade lymphoma had radiotherapy. Four patients with high-grade lymphoma received chemotherapy then radiotherapy. Ten patients are in complete remission after treatment achievement. Five and 10 years disease-free survival are 100%. No severe toxicity was seen.
CONCLUSION
Eradication of Helicobacter pylori is the mainstay of treatment of gastric MALT. External irradiation is an effective and well-tolerated treatment modality in case of resistance to helicobacter eradication.
目的
我们旨在评估放射治疗胃黏膜相关淋巴组织（MALT）淋巴瘤的治疗效果。
患者与方法
我们回顾性分析了1993年至2014年间接受治疗的11例胃MALT淋巴瘤患者的记录。幽门螺杆菌根除治疗失败的低级别淋巴瘤患者仅接受胃外放射治疗。高级别淋巴瘤患者则先进行化疗再进行放射治疗。放射治疗剂量范围为30至40Gy（每次分割2Gy，每周五次分割）。
结果
所有肿瘤均为IE期。7例低级别淋巴瘤患者接受了放射治疗。4例高级别淋巴瘤患者先接受化疗，然后接受放射治疗。10例患者治疗后完全缓解。5年和10年无病生存率均为100%。未观察到严重毒性反应。
结论
根除幽门螺杆菌是胃MALT淋巴瘤治疗的主要方法。在幽门螺杆菌根除治疗耐药的情况下，外照射是一种有效且耐受性良好的治疗方式。
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