Mori Y, Hoshi H, Jinnouchi S, Harada K, Onoe K, Nagamachi S, Ozawa M, Watanabe K, Tawara Y
Radioisotopes. 1987 Feb;36(2):78-80. doi: 10.3769/radioisotopes.36.2_78.
Serum neuron-specific enolase (NSE) levels were studied in 105 patients with malignant neoplasms (lung cancer 38, others 67), 13 patients with various benign diseases and 7 healthy adults. The mean serum NSE level in adult control subjects was 7.4 +/- 0.8 ng/ml, and cut off level was decided 10 ng/ml. Serum NSE levels were elevated in 14/38 (37%) of patients with lung cancer and in 14/67 (21%) of patients with the other malignant neoplasms. In patients with benign diseases, serum NSE level was elevated only in one patient with pituitary adenoma. In 7 patients with small cell lung cancer, the positive rate was higher (86%) than in those with non-small cell lung cancer (26%), and serum NSE levels were higher than 25 ng/ml except one case. There was no correlation between serum NSE and CEA (carcinoembryonic antigen) levels in patients with small cell lung cancer, also in patients with lung cancer. The measurement of serum NSE level seemed to be useful for diagnosis in patients with small cell lung cancer.
对105例恶性肿瘤患者（肺癌38例，其他恶性肿瘤67例）、13例患有各种良性疾病的患者以及7名健康成年人的血清神经元特异性烯醇化酶（NSE）水平进行了研究。成年对照受试者的血清NSE平均水平为7.4±0.8 ng/ml，临界值定为10 ng/ml。14/38（37%）的肺癌患者和14/67（21%）的其他恶性肿瘤患者血清NSE水平升高。在患有良性疾病的患者中，仅1例垂体腺瘤患者血清NSE水平升高。7例小细胞肺癌患者的阳性率（86%）高于非小细胞肺癌患者（26%），除1例外，血清NSE水平均高于25 ng/ml。小细胞肺癌患者以及肺癌患者中，血清NSE与癌胚抗原（CEA）水平之间均无相关性。血清NSE水平的测定似乎对小细胞肺癌患者的诊断有用。
