Aalborg University, Department of Health Science and Technology, Aalborg, 9220, Denmark.
Aalborg University Hospital, Department of Cardiology, Aalborg, 9000, Denmark.
Sci Rep. 2018 Oct 18;8(1):15455. doi: 10.1038/s41598-018-33675-6.
The purpose of this work is to define fiducial points in the seismocardiogram (SCG) and to correlate them with physiological events identified in ultrasound images. For 45 healthy subjects the SCG and the electrocardiogram (ECG) were recorded simultaneously at rest. Immediately following the SCG and ECG recordings ultrasound images of the heart were also obtained at rest. For all subjects a mean SCG signal was calculated and all fiducial points (peaks and valleys) were identified and labeled in the same way across all signals. Eight physiologic events, including the valve openings and closings, were annotated from ultrasound as well and the fiducial points were correlated with those physiologic events. A total of 42 SCG signals were used in the data analysis. The smallest mean differences (±SD) between the eight events found in the ultrasound images and the fiducial points, together with their correlation coefficients (r) were: atrial systolic onset: -2 (±16) ms, r = 0.75 (p < 0.001); peak atrial inflow: 13 (±19) ms, r = 0.63 (p < 0.001); mitral valve closure: 4 (±11) ms, r = 0.71 (p < 0.01); aortic valve opening: -3 (±11) ms, r = 0.60 (p < 0.001); peak systolic inflow: 13 (±23) ms, r = 0.42 (p < 0.01); aortic valve closure: -5 (±12) ms, r = 0.94 (p < 0.001); mitral valve opening: -7 (±19) ms, r = 0.87 (p < 0.001) and peak early ventricular filling: -18 (±28 ms), r = 0.79 (p < 0.001). In conclusion eight physiologic events characterizeing the cardiac cycle, are associated with reproducible, well-defined fiducial points in the SCG.
本研究旨在定义心震图（SCG）中的基准点，并将其与超声图像中识别的生理事件相关联。对 45 名健康受试者进行了静息状态下同步记录 SCG 和心电图（ECG）。在记录 SCG 和 ECG 后，立即对心脏进行超声检查。对所有受试者均计算平均 SCG 信号，并在所有信号中以相同的方式识别和标记所有基准点（峰和谷）。同样，从超声图像中标记出包括瓣膜开闭在内的 8 个生理事件，并将这些基准点与这些生理事件相关联。在数据分析中使用了总共 42 个 SCG 信号。在超声图像和基准点中发现的 8 个事件之间的最小平均差异（±SD）及其相关系数（r）分别为：心房收缩起始：-2（±16）ms，r=0.75（p<0.001）；峰值心房流入：13（±19）ms，r=0.63（p<0.001）；二尖瓣关闭：4（±11）ms，r=0.71（p<0.01）；主动脉瓣开放：-3（±11）ms，r=0.60（p<0.001）；收缩期峰值流入：13（±23）ms，r=0.42（p<0.01）；主动脉瓣关闭：-5（±12）ms，r=0.94（p<0.001）；二尖瓣开放：-7（±19）ms，r=0.87（p<0.001）；早期心室充盈峰值：-18（±28ms），r=0.79（p<0.001）。总之，8 个描述心动周期的生理事件与 SCG 中可重复的、定义明确的基准点相关联。
