Agam Ahmad, Agam Ali, Korsgaard Emil, Yding Troels, Kristensen Charlotte Burup, Mogelvang Rasmus, Kragholm Kristian, Emerk Kasper Janus Grønn, Søgaard Peter, Schmidt Samuel Emil
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Eur Heart J Digit Health. 2025 Apr 16;6(4):811-821. doi: 10.1093/ehjdh/ztaf037. eCollection 2025 Jul.
This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD).
Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG was compared with transthoracic echocardiography (TTE) before and after infusion of 2 L of isotonic saline. Nine subjects (34%) with CVD did not tolerate the full infusion (2 L infusion intolerant), while the remaining 17 subjects (2 L infusion tolerant) successfully completed the infusion. Significant changes in SCG measurements were observed after infusion, including amplitudes Ls (19%, = 0.015), Dd (23%, = 0.016), and Ed (48%, < 0.001) as well as most time intervals. TTE measurements also showed post-infusion changes in stroke volume (15%, = 0.038), mitral annular velocity (7%, = 0.013), left ventricular ejection time (1%, = 0.035), and global longitudinal strain (6%, = 0.003). Although SCG did not detect differences between the healthy and CVD groups, the diastolic amplitude Cd-Dd significantly differed between the infusion tolerant and intolerant groups (pre-infusion: 7.7 vs. 3.7 mg, = 0.046; post-infusion: 8.3 vs. 4.1 mg, = 0.034).
SCG can detect changes in pre-load in both healthy subjects and subjects with CVD. SCG were also able to detect differences in SCG diastolic amplitudes between infusion-tolerant and -intolerant subjects, which may indicate ability to detect diastolic dysfunction and differences in left ventricular filling pressures.
本研究旨在测试地震心音图（SCG）能否检测负荷条件的变化，并检测健康个体与心血管疾病（CVD）患者之间SCG信号的显著差异。
纳入26名受试者（年龄45±16岁，77%为男性），其中11名健康受试者和15名CVD受试者。在输注2L等渗盐水前后，将SCG与经胸超声心动图（TTE）进行比较。9名（34%）CVD受试者不能耐受全部输注量（2L输注不耐受），而其余17名受试者（2L输注耐受）成功完成输注。输注后观察到SCG测量值有显著变化，包括振幅Ls（19%，P = 0.015）、Dd（23%，P = 0.016）和Ed（48%，P < 0.001）以及大多数时间间隔。TTE测量值也显示输注后每搏输出量（15%，P = 0.038）、二尖瓣环速度（7%，P = 0.013）、左心室射血时间（1%，P = 0.035）和整体纵向应变（6%，P = 0.003）发生变化。虽然SCG未检测到健康组与CVD组之间的差异，但输注耐受组与不耐受组之间的舒张期振幅Cd - Dd有显著差异（输注前：7.7 vs. 3.7mg，P = 0.046；输注后：8.3 vs. 4.1mg，P = 0.034）。
SCG能够检测健康受试者和CVD受试者的前负荷变化。SCG还能够检测输注耐受和不耐受受试者之间SCG舒张期振幅的差异，这可能表明其能够检测舒张功能障碍和左心室充盈压力的差异。
