Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Department of Radiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Sci Rep. 2018 Oct 18;8(1):15384. doi: 10.1038/s41598-018-33736-w.
Substitutes for bone grafts experience increasing popularity, but the need for defect-filling following simple curettage of benign bone lesions is controversial. In this study, we wish to objectively report the radiological changes following bone defect-filling using a composite ceramic bone graft substitute, as well as the clinical results and complications. We evaluated 35 surgically treated benign bone lesions with subsequent defect-filling using two variants of a composite ceramic bone graft substitute (CERAMENT|BONE VOID FILLER or CERAMENT|G, BONESUPPORT AB, SWEDEN). After one year, a normal cortical thickness surrounding the defect was seen in approximately 80% of patients. Inside the defect-cavity, an almost complete product-resorption was seen after one year. The most common complication was a post-operative inflammatory soft-tissue reaction, seen in 7 patients (20%), which resolved without further treatment, although short-term antibiotic treatment was initiated at a local hospital in 6 patients, due to suspected wound infection. In summary, cortical thickness most commonly normalizes after bone tumor removal and filling of the bone defect using this particular composite ceramic bone graft substitute. The ceramic substitute undergoes resorption, which causes progressive changes in the radiological appearance inside the bone defect.
骨移植替代物的应用日益普及，但良性骨病变单纯刮除术后是否需要进行骨缺损填充仍存在争议。本研究旨在客观报告使用复合陶瓷骨移植替代物（CERAMENT|BONE VOID FILLER 或 CERAMENT|G，BONESUPPORT AB，SWEDEN）进行骨缺损填充后的影像学变化，以及临床结果和并发症。我们评估了 35 例接受手术治疗的良性骨病变患者，术后采用两种复合陶瓷骨移植替代物（CERAMENT|BONE VOID FILLER 或 CERAMENT|G，BONESUPPORT AB，SWEDEN）进行骨缺损填充。1 年后，约 80%的患者骨缺损周围皮质厚度恢复正常。1 年后，缺损腔内的产品几乎完全吸收。最常见的并发症是术后炎症性软组织反应，7 例（20%）患者出现该并发症，但无需进一步治疗即可缓解，尽管 6 例患者在当地医院因疑似伤口感染而短期接受抗生素治疗。总之，使用这种特殊的复合陶瓷骨移植替代物进行骨肿瘤切除和骨缺损填充后，皮质厚度通常会恢复正常。陶瓷替代物会发生吸收，导致骨缺损内的影像学表现逐渐发生变化。
