Ahmadi Fatemeh
Department of Gynecology and Obstetrics, Zahedan University of Medical Sciences, Zahedan, Iran.
J Adv Pharm Technol Res. 2018 Jul-Sep;9(3):102-106. doi: 10.4103/japtr.JAPTR_297_18.
Postpartum hemorrhage is one of the main causes of mothers' death mostly in developing country. The frequency of postpartum hemorrhage after natural pregnancy and cesarean are reported 2%-4% and 6%, respectively. The main goal of this study is to compare two regimens of oxytocine: One with high dose and the other with normal one to prevent uterine atony. The study has been done via a clinical trial method on 150 pregnant women in Zahedan, Iran. The society is randomly divided into two groups. The patients having risk factors of uterine atony and postpartum hemorrhage were omitted from the list. Oxytocin with 80 and 30 dose was, respectively, infused in 500 cc Ringer serum for control and witness group immediately after infant emersion during a period of 30 min. Decline of hemoglobin 6 and 24 h after cesarean section, uterine atony, blood infusion, and extra uterotonic drug needs after oxytocin infusion have been measured for both groups. The data have been analyzed using Chi-square via SPSS software. The result indicates that there exist meaningful differences between control and witness group in uterine atony and extra utertonic drug need while and after surgery (0 as compared with 22.6% and = 0); whereas there is no significant difference between control and trial group in decline of hemoglobin 6 and 24 h after cesarean section ( = 0.714 and 0.231, respectively). It means that oxytocin infusion with 80 dose has a good impact on the above four variances. It is recommended that oxytocin infusion with 80 dose during a period of 30 min could be a good substitution for oxytocin infusion with 30 dose for the prevention of uterine atony during and after cesarean delivery, especially when utertonic drug is not accessible and in the case of counterindication of other drugs' use.
产后出血是导致母亲死亡的主要原因之一，在发展中国家尤为常见。据报道，自然妊娠和剖宫产术后产后出血的发生率分别为2%-4%和6%。本研究的主要目的是比较两种催产素方案：一种是高剂量方案，另一种是常规剂量方案，以预防子宫收缩乏力。该研究通过临床试验方法，对伊朗扎赫丹的150名孕妇进行了研究。将这些孕妇随机分为两组。有子宫收缩乏力和产后出血危险因素的患者被排除在研究之外。在婴儿娩出后立即将80单位和30单位的催产素分别加入500毫升林格氏液中，在30分钟内分别输注给对照组和观察组。测量两组剖宫产术后6小时和24小时血红蛋白的下降情况、子宫收缩乏力、输血情况以及输注催产素后额外使用宫缩剂的需求。使用SPSS软件通过卡方检验对数据进行分析。结果表明，对照组和观察组在手术期间和术后子宫收缩乏力和额外使用宫缩剂的需求方面存在显著差异（分别为0与22.6%，P = 0）；而对照组和试验组在剖宫产术后6小时和24小时血红蛋白下降方面无显著差异（分别为P = 0.714和0.231）。这意味着80单位剂量的催产素输注对上述四个变量有良好的影响。建议在剖宫产术中及术后30分钟内输注80单位剂量的催产素，可很好地替代30单位剂量的催产素输注，用于预防子宫收缩乏力，尤其是在无法获得宫缩剂以及其他药物使用存在禁忌的情况下。
