Angsubhakorn S, Moe J B, Latendresse J R, Ward G S, Ngamprochana M, Sahaphong S, Bhamarapravati N
Southeast Asian J Trop Med Public Health. 1986 Dec;17(4):604-12.
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
在食蟹猴（猕猴）中研究了减毒登革热2型和黄热病（YF）疫苗病毒、登革热2型（DEN-2）和日本脑炎（JE）病毒的神经毒力特性。比较了出现神经毒力（NV）损伤的中枢神经系统部位数量（以受影响比例计）。结果表明，这些猴子接种JE或YF疫苗病毒后会可靠地出现NV损伤（87%）。接种DEN-2疫苗病毒后，少数猴子出现NV损伤，严重程度最低（9%），可能在生物学上无显著意义，且严重程度与亲代病毒所致损伤相同或更低（10%）。
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