Henchal E A, Putnak J R
Department of Virus Diseases, Walter Reed Army Institute of Research, Washington 20307-5100.
Clin Microbiol Rev. 1990 Oct;3(4):376-96. doi: 10.1128/CMR.3.4.376.
Dengue, a major public health problem throughout subtropical and tropical regions, is an acute infectious disease characterized by biphasic fever, headache, pain in various parts of the body, prostration, rash, lymphadenopathy, and leukopenia. In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. Four distinct serotypes of the dengue virus (dengue-1, dengue-2, dengue-3, and dengue-4) exist, with numerous virus strains found worldwide. Molecular cloning methods have led to a greater understanding of the structure of the RNA genome and definition of virus-specific structural and nonstructural proteins. Progress towards producing safe, effective dengue virus vaccines, a goal for over 45 years, has been made.
登革热是一种主要在亚热带和热带地区出现的重大公共卫生问题，是一种急性传染病，其特征为双相热、头痛、身体各部位疼痛、极度虚弱、皮疹、淋巴结病和白细胞减少。在更严重或复杂的登革热病例中，患者会出现以止血异常和血管通透性增加为特征的严重发热性疾病，在某些情况下会导致低血容量性休克。登革热病毒有四种不同的血清型（登革热-1型、登革热-2型、登革热-3型和登革热-4型），在全球发现了众多病毒株。分子克隆方法使人们对RNA基因组的结构以及病毒特异性结构蛋白和非结构蛋白有了更深入的了解。在生产安全、有效的登革热病毒疫苗方面已取得进展，这是45多年来一直追求的目标。
