Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, PR China.
TOF-PET/CT/MR center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China.
Nanomedicine (Lond). 2018 Oct;13(20):2551-2562. doi: 10.2217/nnm-2018-0051. Epub 2018 Oct 19.
To demonstrate the feasibility of intratracheal administration in orthotopic lung cancer model with F MRI.
MATERIALS & METHODS: αβ-integrin targeting ability of the perfluorocarbon (PFC) nanoparticles was tested. Orthotopic lung cancer model was established in rabbits under computed tomography guidance. αβ-targeted PFC nanoparticles were administrated intratracheally or intravenously, and F MRI was performed before and up to 24 h after administration.
The targeted PFC nanoparticles could bind with αβ-integrin. PFC concentrations in the tumors of intratracheal group after administration were significantly higher than intravenous group.
Intratracheal administration of PFC nanoparticles was shown to be feasible and efficacious. F MRI with αβ-targeted PFC nanoparticles provided quantitative assessment of nanoparticles distribution and tumor angiogenesis.
通过 F MRI 演示经气管内给药在原位肺癌模型中的可行性。
检测全氟化碳（PFC）纳米颗粒的 αβ-整合素靶向能力。在计算机断层扫描引导下，在兔中建立原位肺癌模型。经气管内或静脉内给予靶向 αβ-PFC 纳米颗粒，并在给药前和给药后 24 小时内进行 F MRI。
靶向 PFC 纳米颗粒可与 αβ-整合素结合。给药后经气管内组肿瘤中的 PFC 浓度明显高于静脉内组。
经气管内给予 PFC 纳米颗粒是可行且有效的。用靶向 αβ-PFC 纳米颗粒的 F MRI 可定量评估纳米颗粒的分布和肿瘤血管生成。
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