NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang 150028, People's Republic of China.
TOF-PET/CT/MR Center, Harbin Medical University, Harbin, Heilongjiang 150028, People's Republic of China.
Int J Nanomedicine. 2020 Oct 2;15:7377-7395. doi: 10.2147/IJN.S255084. eCollection 2020.
Fluorine-19 (F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.
氟-19（F）磁共振（MR）分子成像作为一种有前途的非侵入性和定量分子成像方法，由于 F 原子在体内的高灵敏度和低内源性背景信号，受到了广泛的研究。全氟碳化合物（PFC）自 20 世纪 70 年代以来一直被用作血液替代品。最近，已经设计了各种 PFC 纳米颗粒来检测和成像生理和病理变化。这些分子成像探针已被开发用于标记细胞、靶向肿瘤中的特定表位、监测预后和治疗效果以及定量描述肿瘤和肿瘤微环境的变化，从而显著提高了预后和治疗效果。本文讨论了 PFC 纳米颗粒在生物医学中 F MR 技术的最新发展和应用，特别强调了配体靶向和定量 F MR 成像方法在肿瘤检测、氧合测量、智能刺激反应和治疗效果监测等方面的应用。
