高原缺氧环境下肠道菌群对药物代谢的影响及合理用药指导。
Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes.
机构信息
School of Pharmacy, Lanzhou University, Lanzhou, 730000, Gansu, China.
Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, Lanzhou, General Hospital, Lanzhou, 730000, Gansu, China.
出版信息
Curr Drug Metab. 2019;20(2):155-165. doi: 10.2174/1389200219666181019145159.
BACKGROUND
Modern features of drug development such as low permeability, low solubility, and improved release affect the interplay of the gut microbiota and drug metabolism. In recent years, studies have established the impact of plateau hypoxia on gut microbiota, where drug use by plateau populations is affected by hypoxia- induced changes in intestinal microflora-mediated drug metabolism.
METHODS
In this review, we summarized the effects of gut microbiota on drug metabolism, and of plateau hypoxia on the intestinal flora, with the aim of providing guidance for the rational use of drugs in high-altitude populations.
RESULTS
The evidence clearly shows that alterations in gut microbiota can affect pro-drug activation, drug inactivation, and the biotransformation of xenobiotics. Additionally, plateau hypoxia alters drug metabolism by affecting intestinal flora.
CONCLUSION
This review provides an overview of the effects of gut microbiota on drug metabolism and provides guidance for rational drug use under hypoxic conditions at high altitudes.
背景
现代药物开发的特点，如低通透性、低溶解度和改善的释放，会影响肠道微生物群和药物代谢之间的相互作用。近年来，研究已经确定了高原缺氧对肠道微生物群的影响，高原人群的药物使用受到缺氧诱导的肠道微生物群介导的药物代谢变化的影响。
方法
在这篇综述中，我们总结了肠道微生物群对药物代谢的影响，以及高原缺氧对肠道菌群的影响，旨在为高原人群合理使用药物提供指导。
结果
有证据清楚地表明，肠道微生物群的改变会影响前药的激活、药物的失活以及外源性物质的生物转化。此外，高原缺氧通过影响肠道菌群来改变药物代谢。
结论
本综述概述了肠道微生物群对药物代谢的影响，并为在高海拔缺氧条件下合理用药提供了指导。
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