Jung Arne, Chen Laura R, Suyemoto M Mitsu, Barnes H John, Borst Luke B
A Clinic for Poultry, University of Veterinary Medicine Hannover, Buenteweg 17, D-30559 Hannover, Germany,
B Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607.
Avian Dis. 2018 Sep;62(3):261-271. doi: 10.1637/11825-030618-Review.1.
Enterococcus cecorum was initially identified as a harmless commensal of the gastrointestinal tract of chickens. However, over the past 15 yr, pathogenic strains of E. cecorum have become a significant cause of morbidity and mortality in broiler breeders, and repeated outbreaks occur, but an environmental reservoir for pathogenic E. cecorum has yet to be identified. Genetic analyses of E. cecorum demonstrate that strains with increased pathogenicity are genetically related and share several putative virulence genes. Pathogenic E. cecorum carry increased antimicrobial resistance compared to commensal strains. These pathogenic strains can be recovered from retail meat and may serve as a reservoir for further spread of antimicrobial resistance among other Enterococcus spp. This review presents the current understanding of the pathogenesis of E. cecorum and briefly discusses antimicrobial resistance in E. cecorum due to the role of Enterococcus spp. in nosocomial infections in people.
盲肠肠球菌最初被鉴定为鸡胃肠道中的无害共生菌。然而，在过去15年里，盲肠肠球菌的致病菌株已成为肉种鸡发病和死亡的重要原因，且疫情反复爆发，但致病盲肠肠球菌的环境储存库尚未确定。对盲肠肠球菌的基因分析表明，致病性增强的菌株在基因上具有相关性，并共享几个假定的毒力基因。与共生菌株相比，致病盲肠肠球菌具有更高的抗菌耐药性。这些致病菌株可从零售肉类中分离出来，并可能成为抗菌耐药性在其他肠球菌属中进一步传播的储存库。本文综述了目前对盲肠肠球菌致病机制的认识，并简要讨论了盲肠肠球菌的抗菌耐药性，因为肠球菌属在人类医院感染中发挥着作用。
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