Zhang Xueyong, Wang Qing, Wang Like, Xiao Hong, Zhang Daming, Liao Rongfeng, Zheng Yongping
Interdisciplinary Division of Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Optom Vis Sci. 2018 Nov;95(11):1027-1034. doi: 10.1097/OPX.0000000000001292.
Corneal biomechanics are becoming increasingly important for clinical evaluation and diagnosis, such as in refractive surgery, glaucoma, and keratoconus. We developed and used a new technique to measure the full-field displacement and strain of the cornea under elevated intraocular pressure in vivo.
In this study, we propose a three-dimensional digital image correlation method for the determination of corneal biomechanical properties.
Corneal deformation change on the rabbit eyeball was investigated under different inflation conditions with intraocular pressure levels of 2.3, 3.3, 5.3, and 6.9 kPa in vivo.
The proposed method was able to measure the displacement of the corneal surface and to construct real-time full-field three-dimensional deformation vector fields and strain mapping. The results show that the strain distribution is not uniform on the corneal surface at each intraocular pressure level. Compression strains, rather than extensile strains, are dominant at the corneal apex region.
This technique has the potential to be used as an assistive tool for the determination of corneal biomechanical properties in ophthalmologic investigations.
角膜生物力学在临床评估和诊断中变得越来越重要，例如在屈光手术、青光眼和圆锥角膜中。我们开发并使用了一种新技术来测量体内眼压升高时角膜的全场位移和应变。
在本研究中，我们提出一种三维数字图像相关方法来确定角膜生物力学特性。
在体内眼压水平分别为2.3、3.3、5.3和6.9 kPa的不同充气条件下，研究兔眼球上的角膜变形变化。
所提出的方法能够测量角膜表面的位移，并构建实时全场三维变形矢量场和应变映射。结果表明，在每个眼压水平下，角膜表面的应变分布并不均匀。在角膜顶点区域，压缩应变而非拉伸应变占主导。
该技术有潜力在眼科研究中用作确定角膜生物力学特性的辅助工具。
