Mirvis S E, Whitley N O, Aisner J, Moody M, Whitacre M, Whitley J E
AJR Am J Roentgenol. 1987 May;148(5):845-7. doi: 10.2214/ajr.148.5.845.
CT studies of the abdomen performed on 72 patients with small-cell carcinoma of the lung were retrospectively reviewed to assess the role of abdominal CT in staging. Forty-four of the 72 patients had extensive disease, defined as disease extending beyond the confines of one hemithorax, plus or minus mediastinal or ipsilateral supraclavicular disease or ipsilateral pleural effusion. Initial-staging abdominal CT revealed one or more sites of metastatic disease in 26 (59%) of these 44 patients, while 18 patients had normal initial CT examinations. Statistical analysis of patients with extensive disease revealed a significant increase in complete therapeutic response (p = .0054) and in the length of survival (p = .001) among those who had extensive disease without abdominal metastases as compared with those who had abdominal metastases on their initial abdominal CT examination. The development of new or recurrent abdominal metastases in general or in specific organs on follow-up scans obtained in 35 patients did not significantly decrease their survival time as compared with that of patients without such metastases. Our findings suggest that CT of the abdomen is beneficial in the initial staging of patients with small-cell carcinoma of the lung and provides prognostic information concerning response to therapy and length of survival.
对72例小细胞肺癌患者进行的腹部CT研究进行了回顾性分析，以评估腹部CT在分期中的作用。72例患者中有44例患有广泛期疾病，定义为疾病超出一侧胸腔范围，伴有或不伴有纵隔或同侧锁骨上疾病或同侧胸腔积液。初始分期腹部CT显示，这44例患者中有26例（59%）有一个或多个转移病灶，而18例患者初始CT检查正常。对广泛期疾病患者的统计分析显示，与初始腹部CT检查有腹部转移的患者相比，无腹部转移的广泛期疾病患者的完全治疗反应（p = 0.0054）和生存期（p = 0.001）有显著增加。在35例患者的随访扫描中，无论总体还是特定器官出现新的或复发性腹部转移，与无此类转移的患者相比，其生存时间并未显著缩短。我们的研究结果表明，腹部CT对小细胞肺癌患者的初始分期有益，并能提供有关治疗反应和生存期的预后信息。
