新型血管紧张素转换酶抑制剂雷米普利对原发性高血压患者血压昼夜变化的影响。
Effect of ramipril, a new angiotensin converting enzyme inhibitor, on diurnal variations of blood pressure in essential hypertension.
作者信息
Kaneko Y, Omae T, Yoshinaga K, Iimura O, Inagaki Y, Ishii M, Saruta T, Yamada K, Kumahara Y, Ito K
出版信息
Am J Cardiol. 1987 Apr 24;59(10):86D-91D. doi: 10.1016/0002-9149(87)90060-9.
The effect of ramipril on diurnal variations of blood pressure was studied in patients with mild to moderate essential hypertension in groups given once- (n = 18) and twice-daily (n = 21) administration with daily dosages ranging from 2.5 to 10 mg. After ramipril treatment, the blood pressure of patients in both groups was significantly reduced, and no significant differences in diurnal variation of blood pressure were observed between the 2 groups. The pulse rate did not change after administration of ramipril and no serious side effects were observed. In consideration of patient compliance, once-daily administration of ramipril seems to be optimal for the treatment of essential hypertension.
在轻度至中度原发性高血压患者中，研究了雷米普利对血压昼夜变化的影响。将患者分为两组，一组每日给药一次（n = 18），另一组每日给药两次（n = 21），日剂量范围为2.5至10毫克。雷米普利治疗后，两组患者的血压均显著降低，两组之间血压的昼夜变化无显著差异。服用雷米普利后脉搏率未改变，且未观察到严重副作用。考虑到患者的依从性，雷米普利每日一次给药似乎是治疗原发性高血压的最佳方式。
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