基于囊泡的分析方法用于研究淀粉样肽的膜相互作用。

Vesicle-Based Assays to Study Membrane Interactions of Amyloid Peptides.

作者信息

Malishev Ravit, Kolusheva Sofiya, Jelinek Raz

机构信息

Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva, Israel.

Ilse Katz Institute for Nanotechnology, Ben Gurion University of the Negev, Beer Sheva, Israel.

出版信息

Methods Mol Biol. 2019;1873:39-51. doi: 10.1007/978-1-4939-8820-4_3.

DOI:10.1007/978-1-4939-8820-4_3

PMID:30341602

Abstract

The growing interest in membrane interactions of amyloidogenic peptides and proteins emanates from the realization that lipid bilayers and membranes play central roles in the toxicity and pathological pathways of amyloid diseases. This chapter presents experimental schemes designed to study membrane interactions and membrane-induced fibrillation of amyloid peptides.

摘要

对淀粉样生成肽和蛋白质与膜相互作用的兴趣日益浓厚，这源于人们认识到脂质双层和膜在淀粉样疾病的毒性和病理途径中起着核心作用。本章介绍了旨在研究淀粉样肽与膜相互作用以及膜诱导的淀粉样肽纤维化的实验方案。