State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Sichuan Nursing Vocational College, Chengdu 610100, China.
Eur J Med Chem. 2019 Jan 1;161:48-77. doi: 10.1016/j.ejmech.2018.10.028. Epub 2018 Oct 15.
Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.
Sirtuin（酵母沉默信息调节因子Ⅱ，Sir2）于 20 世纪 70 年代首次被发现。由于其在烟酰胺腺嘌呤二核苷酸（NAD）存在的情况下从组蛋白上去除乙酰化基团的功能，一波又一波的研究评估了 Sirtuin 作为治疗靶点的潜力。Sirtuin 家族广泛存在于自然界中，已被分为七种人类同工酶（Sirt1-Sirt7）。它们被认为与一些衰老疾病密切相关，如心血管疾病、神经退行性疾病和肿瘤。在此，我们对 Sirtuins 的结构、功能和调节剂进行了全面综述，以期对相关研究有所裨益。
