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钾在青蛙半规管功能中的重要性。

The importance of potassium in the function of frog semicircular canals.

作者信息

Valli P, Zucca G, Casella C

出版信息

Acta Otolaryngol. 1977 Nov-Dec;84(5-6):344-51. doi: 10.3109/00016487709123976.

DOI:10.3109/00016487709123976
PMID:303425
Abstract

The slow potentials and afferent discharge of impulses in frog semicircular canals have been studied at different endolymphatic and perilymphatic K+ concentrations. Results indicate that the presence of K ions in the bathing fluids is essential for maintaining the receptor function in crista ampullaris, although very low concentrations of this ion in the perilymph are sufficient to preserve the receptor responsiveness to mechanical stimuli. The hypothesis is put forward that K+ may be pumped from the exterior of the canal towards the intracupular structures, where it accumulates. A K-rich endolymphatic environment does, however, appear to be necessary to ensure the resting activity of ampullar receptors and their ability to be "disfacilitated" during inhibitory cupula deflections.

摘要

在不同的内淋巴和外淋巴钾离子浓度条件下,对青蛙半规管中的慢电位和传入冲动放电进行了研究。结果表明,尽管外淋巴中这种离子的浓度非常低就足以维持感受器对机械刺激的反应性,但浴液中钾离子的存在对于维持壶腹嵴的感受器功能至关重要。有人提出假说,钾离子可能从半规管外部被泵入壶腹帽内结构并在那里积聚。然而,富含钾离子的内淋巴环境似乎对于确保壶腹感受器的静息活动以及它们在抑制性壶腹帽偏移期间“去易化”的能力是必要的。

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3
Electrical activity of isolated semicircular canal in the frog. Action of streptomycin.
青蛙离体半规管的电活动。链霉素的作用。
Pflugers Arch. 1980 Nov;388(2):93-9. doi: 10.1007/BF00584114.
4
Perilymphatic potassium changes and potassium homeostasis in isolated semicircular canals of the frog.青蛙离体半规管内的外淋巴钾变化及钾稳态
J Physiol. 1990 Nov;430:585-94. doi: 10.1113/jphysiol.1990.sp018308.