哮喘中的支气管激发试验：最新进展

Bronchoprovocation Testing in Asthma: An Update.

作者信息

Comberiati Pasquale, Katial Rohit K, Covar Ronina A

机构信息

Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, 56126 Pisa, Italy; Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.

National Jewish Health, 1400 Jackson Street (J321), Denver, CO 80206, USA.

出版信息

Immunol Allergy Clin North Am. 2018 Nov;38(4):545-571. doi: 10.1016/j.iac.2018.06.010.

DOI:10.1016/j.iac.2018.06.010

PMID:30342579

Abstract

Bronchial hyperresponsiveness (BHR) is defined as a heightened bronchoconstrictive response to airway stimuli. It complements the cardinal features in asthma, such as variable or reversible airflow limitation and airway inflammation. Although BHR is considered a pathophysiologic hallmark of asthma, it should be acknowledged that this property of the airway is dynamic, because its severity and even presence can vary over time with disease activity, triggers or specific exposure, and with treatment. In addition, it is important to recognize that there is a component that is not reflective of a specific disease entity.

摘要

支气管高反应性（BHR）被定义为对气道刺激的支气管收缩反应增强。它补充了哮喘的主要特征，如可变或可逆的气流受限和气道炎症。尽管BHR被认为是哮喘的病理生理标志，但应该认识到气道的这一特性是动态的，因为其严重程度甚至是否存在会随疾病活动、触发因素或特定暴露以及治疗而随时间变化。此外，重要的是要认识到存在一个并非反映特定疾病实体的组成部分。