脊椎动物甘氨酸受体蛋白。
The vertebrate glycine receptor protein.
作者信息
Betz H, Schmitt B, Becker C M, Grenningloh G, Rienitz A
出版信息
Biochem Soc Symp. 1986;52:57-63.
Glycine is a major inhibitory neurotransmitter in the central nervous system. The postsynaptic receptor for this amino acid is a transmembrane ion channel protein which, after affinity purification on an antagonist column, contains three polypeptides of Mr 48,000, 58,000 and 93,000. Biochemical and immunological data show that these polypeptides have different functional properties and topologies with respect to the postsynaptic membrane. A model summarizing the currently available structural data is presented.
甘氨酸是中枢神经系统中的一种主要抑制性神经递质。这种氨基酸的突触后受体是一种跨膜离子通道蛋白，在拮抗剂柱上进行亲和纯化后，它包含分子量分别为48,000、58,000和93,000的三种多肽。生化和免疫学数据表明，这些多肽相对于突触后膜具有不同的功能特性和拓扑结构。本文提出了一个总结当前可用结构数据的模型。
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