Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedar Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University Health System, Seoul, South Korea.
Yonsei-Cedar Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University Health System, Seoul, South Korea; Division of Cardiology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.
J Cardiovasc Comput Tomogr. 2019 Jan-Feb;13(1):48-54. doi: 10.1016/j.jcct.2018.09.012. Epub 2018 Oct 1.
The present study aimed to assess the reliability and reproducibility of coronary computed tomography angiography (CCTA) for the serial quantitative assessment of plaque volume.
Patients who underwent repeated CCTA scans within 90 days were retrospectively screened and enrolled. Clinical data and CCTA imaging data were collected. Paired CCTA scans were analyzed using the quantitative method by separate observers blinded to the other paired CCTA scans. Results were compared between the index CCTA and follow-up CCTA.
Paired CT scans of 95 patients (61 ± 13 years; 56.8% men) with same tube voltages (kVp) at both CCTAs and 24 patients (57 ± 19 years; 48.3% men) with different kVp at two CCTAs were analyzed. In patients with same kVp at both CCTAs, there were no difference in PV and PVs of each components in per-segment analysis and per-lesion analysis (all p > 0.05). In per-lesion analysis of CCTAs from patients who used different kVp between two CCTAs, lesion length, area and diameter stenosis, and PVs were not different between index and follow-up CCTAs (all p > 0.05). Segment length and PV were also showed no difference between two serial CCTAs in per-segment analysis.
We showed the reproducibility and reliability of quantitative analysis of CCTA for assessment of coronary plaques. CCTA can be applied for the serial quantitative assessment of coronary artery disease progression, regardless of differences in the image acquisition protocol.
本研究旨在评估冠状动脉 CT 血管造影（CCTA）在斑块体积的连续定量评估中的可靠性和可重复性。
回顾性筛选并纳入在 90 天内接受重复 CCTA 扫描的患者。收集临床数据和 CCTA 成像数据。通过分别对其他配对 CCTA 扫描不知情的两位观察者，使用定量方法分析配对 CCTA 扫描。将指数 CCTA 和随访 CCTA 的结果进行比较。
分析了 95 例患者（61±13 岁；56.8%为男性）在两次 CCTA 时采用相同管电压（kVp）和 24 例患者（57±19 岁；48.3%为男性）在两次 CCTA 时采用不同 kVp 的配对 CT 扫描。在两次 CCTA 时采用相同 kVp 的患者中，在节段和病变水平的定量分析中，斑块总体积（PV）和各成分的 PV 均无差异（均 P>0.05）。在两次 CCTA 中采用不同 kVp 的患者的病变水平分析中，病变长度、面积和直径狭窄程度以及 PV 在指数和随访 CCTA 之间均无差异（均 P>0.05）。在节段水平的定量分析中，两个连续 CCTA 的节段长度和 PV 也无差异。
我们表明了 CCTA 用于评估冠状动脉斑块的定量分析的可重复性和可靠性。无论图像采集方案的差异如何，CCTA 均可应用于冠状动脉疾病进展的连续定量评估。
