Guo Ge, Zhou Juhua, Yang Xiaogaung, Feng Jiang, Shao Yanxia, Jia Tingting, Huang Qingrong, Li Yanmin, Zhong Yin, Nagarkatti Prakash S, Nagarkatti Mitzi
1 Ludong University, Yantai, Shandong, People's Republic of China.
2 Hangzhou Hesti Biotechnology Co, Ltd, Hangzhou, Zhejiang, People's Republic of China.
Integr Cancer Ther. 2018 Dec;17(4):1059-1067. doi: 10.1177/1534735418805564. Epub 2018 Oct 20.
MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate gene expression, and consequently several important functions including early embryo development, cell cycle, programmed cell death, cell differentiation, and metabolism. While there are no effective treatments available against hepatocellular carcinoma (HCC), some Chinese herbal medicines have been shown to regulate growth, differentiation, invasion, and metastasis of HCC. Many studies have shown that Chinese herbal medicines regulate the expression of miRNAs and this may be associated with their ability to control the development of HCC. In this article, the effects of Chinese herbal medicines on the expression of miRNAs and their functions in the regulation of HCC have been reviewed and discussed. miRNAs such as miRNA-221 and miRNA-222 mediated by Chinese herbal medicines may be good biomarkers and therapeutic targets for HCC.
微小RNA（miRNA）是高度保守的非编码小RNA，可调节基因表达，进而调控包括早期胚胎发育、细胞周期、程序性细胞死亡、细胞分化和代谢在内的多种重要功能。虽然目前尚无有效的肝细胞癌（HCC）治疗方法，但一些中草药已被证明可调节HCC的生长、分化、侵袭和转移。许多研究表明，中草药可调节miRNA的表达，这可能与其控制HCC发展的能力有关。本文对中草药对miRNA表达的影响及其在HCC调控中的作用进行了综述和讨论。由中草药介导的miRNA-221和miRNA-222等miRNA可能是HCC的良好生物标志物和治疗靶点。
