• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

混合弧形调强放疗与容积调强弧形放疗用于颅内立体定向分次放疗的治疗计划评估

Evaluation of Hybrid Arc and Volumetric-Modulated Arc Therapy Treatment Plans for Fractionated Stereotactic Intracranial Radiotherapy.

作者信息

Li Jun, To David, Gunn Vickie, Shi Wenyin, Yu Yan, Liu Haisong

机构信息

1 Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

Technol Cancer Res Treat. 2018 Jan 1;17:1533033818802804. doi: 10.1177/1533033818802804.

DOI:10.1177/1533033818802804
PMID:30343652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6198396/
Abstract

PURPOSE

The study was aimed to compare hybrid arc and volumetric-modulated arc therapy treatment plans for fractionated stereotactic radiotherapy of brain tumors.

METHODS

Treatment plans of 22 patients were studied. Hybrid arc and volumetric-modulated arc therapy plans were generated using Brainlab iPlanDose and Varian Eclipse treatment planning systems, respectively, with 6 MV photon beams on a Varian TrueBeam STx linear accelerator (Palo Alto, CA). Prescription dose was 54 Gy. The fractionation was 1.8 Gy per fraction and 30 fractions in total, or 2 Gy per fraction and 27 fractions in total. Planning target volume ranged from 2.4 to 28.6 cm. Dose conformity index, gradient index, homogeneity index, and maximum doses in organs at risk were compared. Wilcoxon signed rank test was used to determine statistical significance in paired comparison.

RESULTS

Conformity indexes of hybrid arc and volumetric-modulated arc therapy plans are 1.10 ± 0.10 and 1.14 ± 0.07, respectively ( P = .4); gradient indexes are 5.02 ± 1.20 and 5.64 ± 1.28, respectively ( P = .0001); homogeneity indexes are 1.02 ± 0.01 and 1.05 ± 0.01, respectively ( P = .0001); brainstem maximum doses are 53.87 ± 1.63 Gy and 54.06 ± 3.17 Gy, respectively ( P = .1); and optic chiasm maximum doses are 53.86 ± 1.28 Gy and 53.95 ± 1.81, respectively ( P = .4). The monitor unit efficiencies of hybrid arc and volumetric-modulated arc therapy plans are 2.57 ± 0.25 MU/cGy and 2.68 ± 0.24 MU/cGy, respectively ( P = .2). The differences of conformity index, gradient index, and homogeneity index between hybrid arc and volumetric-modulated arc therapy plans are small: 0.08 ± 0.05, 0.65 ± 0.46, and 0.02 ± 0.01, respectively. The maximum doses in organs at risks are similar between hybrid arc and volumetric-modulated arc therapy plans. Hybrid arc and volumetric-modulated arc therapy plans, which have similar monitor unit efficiencies, present similar dosimetric results in the fractionated intracranial radiotherapy.

摘要

目的

本研究旨在比较混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）治疗计划在脑肿瘤分割立体定向放疗中的应用。

方法

研究了22例患者的治疗计划。分别使用Brainlab iPlanDose和Varian Eclipse治疗计划系统生成混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划，在Varian TrueBeam STx直线加速器（加利福尼亚州帕洛阿尔托）上使用6 MV光子束。处方剂量为54 Gy。分割方式为每次1.8 Gy，共30次，或每次2 Gy，共27次。计划靶体积范围为2.4至28.6 cm³。比较了剂量适形指数、梯度指数、均匀性指数以及危及器官的最大剂量。采用Wilcoxon符号秩检验确定配对比较中的统计学意义。

结果

混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划的适形指数分别为1.10±0.10和1.14±0.07（P = 0.4）；梯度指数分别为5.02±1.20和5.64±1.28（P = 0.0001）；均匀性指数分别为1.02±0.01和1.05±0.01（P = 0.0001）；脑干最大剂量分别为53.87±1.63 Gy和54.06±3.17 Gy（P = 0.1）；视交叉最大剂量分别为53.86±1.28 Gy和53.95±1.81（P = 0.4）。混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划的监测单位效率分别为2.57±0.25 MU/cGy和2.68±0.24 MU/cGy（P = 0.2）。混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划在适形指数、梯度指数和均匀性指数上的差异较小：分别为0.08±0.05、0.65±0.46和0.02±0.01。混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划在危及器官的最大剂量方面相似。混合弧形调强放疗（VMAT）和容积弧形调强放疗（VMAT）计划具有相似的监测单位效率，在分割颅内放疗中呈现相似的剂量学结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/904984b5f5f9/10.1177_1533033818802804-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/01876c5486b3/10.1177_1533033818802804-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/ed9df5d5a24d/10.1177_1533033818802804-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/fb71ba3a026f/10.1177_1533033818802804-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/aebc06d17210/10.1177_1533033818802804-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/8fd0c791c1d5/10.1177_1533033818802804-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/c79c88cb06a5/10.1177_1533033818802804-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/bf3b0df072ea/10.1177_1533033818802804-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/904984b5f5f9/10.1177_1533033818802804-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/01876c5486b3/10.1177_1533033818802804-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/ed9df5d5a24d/10.1177_1533033818802804-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/fb71ba3a026f/10.1177_1533033818802804-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/aebc06d17210/10.1177_1533033818802804-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/8fd0c791c1d5/10.1177_1533033818802804-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/c79c88cb06a5/10.1177_1533033818802804-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/bf3b0df072ea/10.1177_1533033818802804-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daf7/6198396/904984b5f5f9/10.1177_1533033818802804-fig8.jpg

相似文献

1
Evaluation of Hybrid Arc and Volumetric-Modulated Arc Therapy Treatment Plans for Fractionated Stereotactic Intracranial Radiotherapy.混合弧形调强放疗与容积调强弧形放疗用于颅内立体定向分次放疗的治疗计划评估
Technol Cancer Res Treat. 2018 Jan 1;17:1533033818802804. doi: 10.1177/1533033818802804.
2
Hypofractionated stereotactic radiotherapy for brain metastases: a dosimetric and treatment efficiency comparison between volumetric modulated arc therapy and intensity modulated radiotherapy.立体定向适形放疗治疗脑转移瘤：容积旋转调强弧形治疗与调强放疗的剂量学和治疗效率比较。
Technol Cancer Res Treat. 2010 Oct;9(5):499-507. doi: 10.1177/153303461000900508.
3
Dosimetric comparison of volumetric modulated arc therapy and linear accelerator-based radiosurgery for the treatment of one to four brain metastases.容积调强弧形放疗与基于直线加速器的放射外科治疗一至四个脑转移瘤的剂量学比较。
J Med Imaging Radiat Oncol. 2014 Dec;58(6):722-8. doi: 10.1111/1754-9485.12188. Epub 2014 Jun 10.
4
Dosimetric characterization of hypofractionated Gamma Knife radiosurgery of large or complex brain tumors versus linear accelerator-based treatments.大体积或复杂脑肿瘤的伽玛刀立体定向放射外科治疗与基于线性加速器的治疗的剂量学特征比较。
J Neurosurg. 2016 Dec;125(Suppl 1):97-103. doi: 10.3171/2016.7.GKS16881.
5
Volumetric modulated arc-based hypofractionated stereotactic radiotherapy for the treatment of selected intracranial arteriovenous malformations: dosimetric report and early clinical experience.容积旋转调强弧形分割立体定向放疗治疗特定颅内动静脉畸形的剂量学报告和早期临床经验。
Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1278-84. doi: 10.1016/j.ijrobp.2011.02.005. Epub 2011 Apr 12.
6
Linac-based VMAT radiosurgery for multiple brain lesions: comparison between a conventional multi-isocenter approach and a new dedicated mono-isocenter technique.基于直线加速器的 VMAT 立体定向放射手术治疗多个脑病变：常规多等中心方法与新专用单等中心技术的比较。
Radiat Oncol. 2018 Mar 5;13(1):38. doi: 10.1186/s13014-018-0985-2.
7
Noncoplanar VMAT for Brain Metastases: A Plan Quality and Delivery Efficiency Comparison With Coplanar VMAT, IMRT, and CyberKnife.非共面容积旋转调强放疗（VMAT）治疗脑转移瘤：与共面容积旋转调强放疗、调强放疗和射波刀比较的计划质量和治疗效率。
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819871621. doi: 10.1177/1533033819871621.
8
Normal Brain Sparing With Increasing Number of Beams and Isocenters in Volumetric-Modulated Arc Beam Radiosurgery of Multiple Brain Metastases.在多脑转移瘤容积调强弧形束放射外科治疗中，随着射束和等中心数量增加实现正常脑组织保护
Technol Cancer Res Treat. 2016 Dec;15(6):766-771. doi: 10.1177/1533034615614208. Epub 2015 Nov 22.
9
Dose fall-off patterns with volumetric modulated arc therapy and three-dimensional conformal radiotherapy including the "organ at risk" effect. Experience of linear accelerator-based frameless radiosurgery from a single institution.容积调强弧形放疗和三维适形放疗的剂量衰减模式，包括“危及器官”效应。来自单一机构的基于直线加速器的无框架放射外科手术经验。
Cancer Radiother. 2019 Apr;23(2):138-146. doi: 10.1016/j.canrad.2018.10.003. Epub 2019 Feb 21.
10
Dosimetric evaluation of adult and paediatric brain tumours planned using mask-based cobalt-60 fractionated stereotactic radiotherapy compared to linear accelerator-based volumetric modulated arc therapy.基于面罩的钴-60 分次立体定向放射治疗与基于直线加速器的容积旋转调强弧形治疗成人和儿童脑肿瘤的剂量学评估。
J Med Radiat Sci. 2023 Mar;70(1):64-71. doi: 10.1002/jmrs.615. Epub 2022 Oct 1.

引用本文的文献

1
Effects of two different radiotherapies for craniopharyngiomas using stereotactic radiosurgery/ stereotactic radiotherapy or fractionated stereotactic radiotherapy.使用立体定向放射外科手术/立体定向放射治疗或分次立体定向放射治疗的两种不同放疗方法对颅咽管瘤的影响。
Surg Neurol Int. 2022 Dec 2;13:563. doi: 10.25259/SNI_802_2022. eCollection 2022.
2
Dosimetric comparison of Gamma Knife® Icon and linear accelerator-based fractionated stereotactic radiotherapy (FSRT) plans for the re-irradiation of large (>14 cm) recurrent glioblastomas.伽玛刀Icon与基于直线加速器的分次立体定向放射治疗（FSRT）计划对大型（>14厘米）复发性胶质母细胞瘤再照射的剂量学比较。
J Radiosurg SBRT. 2021;7(3):233-243.

本文引用的文献

1
Comparison between Dual Arc VMAT and 7F-IMRT in the protection of hippocampus for patients during whole brain radiotherapy.
J Xray Sci Technol. 2016 Mar 17;24(3):457-66. doi: 10.3233/XST-160561.
2
Whole brain radiotherapy with adjuvant or concomitant boost in brain metastasis: dosimetric comparison between helical and volumetric IMRT technique.全脑放疗联合辅助或同步加量治疗脑转移瘤：螺旋断层放疗与容积调强放疗技术的剂量学比较
Radiat Oncol. 2016 Apr 19;11:59. doi: 10.1186/s13014-016-0634-6.
3
Fractionated stereotactic radiotherapy of benign skull-base tumors: a dosimetric comparison of volumetric modulated arc therapy with Rapidarc® versus non-coplanar dynamic arcs.良性颅底肿瘤的分次立体定向放射治疗：容积调强弧形放疗（Rapidarc®）与非共面动态弧形放疗的剂量学比较
Radiat Oncol. 2016 Apr 18;11:58. doi: 10.1186/s13014-016-0632-8.
4
Dosimetric study of different radiotherapy planning approaches for hippocampal avoidance whole-brain radiation therapy (HA-WBRT) based on fused CT and MRI imaging.基于融合CT和MRI成像的海马回避全脑放射治疗（HA-WBRT）不同放疗计划方法的剂量学研究。
Australas Phys Eng Sci Med. 2015 Dec;38(4):767-75. doi: 10.1007/s13246-015-0397-7. Epub 2015 Nov 17.
5
Optimization of Craniospinal Irradiation for Pediatric Medulloblastoma Using VMAT and IMRT.使用容积调强弧形放疗（VMAT）和调强放疗（IMRT）对儿童髓母细胞瘤进行颅脊髓照射的优化
J Pediatr Hematol Oncol. 2015 Oct;37(7):e405-11. doi: 10.1097/MPH.0000000000000418.
6
Whole-brain hippocampal sparing radiation therapy: Volume-modulated arc therapy vs intensity-modulated radiation therapy case study.全脑海马区保留放射治疗：容积调强弧形放疗与调强放射治疗病例研究
Med Dosim. 2016 Spring;41(1):15-21. doi: 10.1016/j.meddos.2015.06.003. Epub 2015 Jul 30.
7
Implementation of HybridArc treatment technique in preoperative radiotherapy of rectal cancer: dose patterns in target lesions and organs at risk as compared to helical Tomotherapy and RapidArc.HybridArc 治疗技术在直肠癌术前放疗中的应用：与螺旋断层放疗和 RapidArc 相比，靶区和危及器官的剂量分布。
Radiat Oncol. 2012 Jul 31;7:120. doi: 10.1186/1748-717X-7-120.
8
HybridArc: a novel radiation therapy technique combining optimized dynamic arcs and intensity modulation.混合弧形放疗技术：一种结合优化动态弧形放疗和调强放疗的新型放射治疗技术。
Med Dosim. 2012 Winter;37(4):358-68. doi: 10.1016/j.meddos.2012.02.001. Epub 2012 Apr 24.
9
Dosimetric comparison of helical tomotherapy, RapidArc, and a novel IMRT & Arc technique for esophageal carcinoma.螺旋断层放疗、RapidArc 与新型调强放疗和弧形技术治疗食管癌的剂量学比较。
Radiother Oncol. 2011 Dec;101(3):431-7. doi: 10.1016/j.radonc.2011.08.030. Epub 2011 Oct 1.
10
Dosimetric comparison of intensity-modulated radiosurgery and helical tomotherapy for the treatment of multiple intracranial metastases.调强放射外科与螺旋断层放射治疗多发性颅内转移瘤的剂量学比较。
Technol Cancer Res Treat. 2009 Oct;8(5):361-7. doi: 10.1177/153303460900800506.