大鼠心室肌膜ATP酶活性——与年龄和钠离子的关系
Sarcolemmal ATPase activities of the rat heart ventricle--dependence on age and sodium ion.
作者信息
Karttunen P, Vornanen M
出版信息
Comp Biochem Physiol B. 1987;86(4):815-20. doi: 10.1016/0305-0491(87)90230-6.
Na-K-ATPase activity of the rat heart was similar throughout the postnatal growth when measured from crude unpurified fraction. Instead in the cardiac sarcolemmal fraction, isolated by hypotonic shock LiBr-treatment method, the activity was over two times higher in 10-day old neonates than in adult rats. The conflicting results are partly explained by different effects of the isolation procedure on neonatal and adult tissues. Na concentration for half-maximal activity of the Na-K-ATPase was similar in neonates (7.0 mM) and adults (6.4 mM). Ca-ATPase activity was not affected by Na concentration (2-100 mM) in the two age-groups studied.
从粗制未纯化组分测量时，大鼠心脏的钠钾ATP酶活性在出生后整个生长过程中相似。相反，通过低渗休克LiBr处理方法分离的心肌肌膜组分中，10日龄新生儿的活性比成年大鼠高两倍以上。这些相互矛盾的结果部分是由于分离程序对新生儿和成年组织的不同影响所致。钠钾ATP酶半最大活性时的钠浓度在新生儿（7.0 mM）和成年人（6.4 mM）中相似。在所研究的两个年龄组中，钙ATP酶活性不受钠浓度（2 - 100 mM）的影响。
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