Wang Hong, Yuan Fei-Fei, Dai Zi-Wei, Wang Bin, Ye Dong-Qing
Anhui Province Key Laboratory of Major Autoimmune Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Int J Rheum Dis. 2018 Sep;21(9):1651-1658. doi: 10.1111/1756-185X.13366.
To evaluate the association between natural resistance-associated macrophage protein 1 (NRAMP1) polymorphisms and rheumatoid arthritis (RA).
All related studies were retrieved and screened from PubMed, CNKI and Web of Science. Pooled odds ratios (ORs) and 95% CIs were assessed for the strength of association between NRAMP1 and RA. Publication bias was measured by Begg's funnel plot and Egger's regression test. The robustness of this meta-analysis was detected by sensitivity analysis.
A total of five eligible publications were included in the present meta-analysis. The polled data showed no association between RA and NRAMP1 D543N and 1729 + 55del4 in the allele model. However, the relationship between RA and NRAMP1 INT4 was statistically significant (OR 1.65, 95% CI 1.14-2.38). Genotypic analysis demonstrated that there were no associations between RA and NRAMP1 D543N, 1729 + 55del4 and INT4 in homozygous comparison (D543N: OR 0.97, 95% CI 0.15-6.09; 1729 + 55del4: OR 1.19, 95% CI 0.29-24.88; INT4: OR 3.18, 95% CI 0.62-16.26), dominant model (D543N: OR 1.04, 95% CI 0.61-61.78; 1729 + 55del4: OR 1.41, 95% CI 0.81-2.47; INT4: OR 1.22, 95% CI 0.72-2.06) and recessive model (D543N: OR 0.93, 95% CI 0.15-5.91; 1729 + 55del4: OR 0.99, 95% CI 0.26-3.86; INT4: OR 2.95, 95% CI 0.61-14.16). In heterozygous comparison, it no association was shown between RA and NRAMP1 D543N and INT4, excepting NRAMP1 1729 + 55del4 (OR 1.73, 95% CI 1.17-2.56). Further subgroup analysis indicated that NRAMP1 1729 + 55del4 and INT4 were related to RA in Asia and in the Hardy-Weinberg equilibrium group. There exists no publication bias in this meta-analysis.
This meta-analysis indicated that NRAMP1 1729 + 55del4 and INT4 confer susceptibility to RA.
评估自然抵抗相关巨噬细胞蛋白1（NRAMP1）基因多态性与类风湿关节炎（RA）之间的关联。
从PubMed、中国知网（CNKI）和科学网（Web of Science）检索并筛选所有相关研究。评估NRAMP1与RA之间关联强度的合并比值比（OR）和95%可信区间（CI）。采用Begg漏斗图和Egger回归检验评估发表偏倚。通过敏感性分析检测本荟萃分析的稳健性。
本荟萃分析共纳入5篇符合条件的文献。汇总数据显示，在等位基因模型中，RA与NRAMP1 D543N和1729 + 55del4之间无关联。然而，RA与NRAMP1 INT4之间的关系具有统计学意义（OR 1.65，95%CI 1.14 - 2.38）。基因型分析表明，在纯合子比较中（D543N：OR 0.97，95%CI 0.15 - 6.09；1729 + 55del4：OR 1.19，95%CI 0.29 - 24.88；INT4：OR 3.18，95%CI 0.62 - 16.26）、显性模型（D543N：OR 1.04，95%CI 0.61 - 61.78；1729 + 55del4：OR 1.41，95%CI 0.81 - 2.47；INT4：OR 1.22，95%CI 0.72 - 2.06）和隐性模型（D543N：OR 0.93，95%CI 0.15 - 5.91；1729 + 55del4：OR 0.99，95%CI 0.26 - 3.86；INT4：OR 2.95，95%CI 0.61 - 14.16）中，RA与NRAMP1 D543N、1729 + 55del4和INT4之间均无关联。在杂合子比较中，除NRAMP1 1729 + 55del4（OR 1.73，95%CI 1.17 - 2.56）外，RA与NRAMP1 D543N和INT4之间无关联。进一步的亚组分析表明，NRAMP1 1729 + 55del4和INT4在亚洲人群以及处于哈迪-温伯格平衡的人群中与RA相关。本荟萃分析不存在发表偏倚。
本荟萃分析表明，NRAMP1 1729 + 55del4和INT4使个体易患RA。
