Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Department of Neurology and Fixel Center for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
Mov Disord. 2019 Jan;34(1):95-104. doi: 10.1002/mds.27522. Epub 2018 Oct 21.
Evidence from functional imaging in essential tremor suggests that activity within parietal and motor cortices may be associated with worsening of tremor at increased visual feedback.
Examine how cortical oscillations within these regions and the connectivity between these regions is associated with worsening of tremor in essential tremor in response to high visual feedback.
The study included 24 essential tremor participants and 17 controls. We measured cortical activity and tremor magnitude at low and high feedback conditions. Cortical activity was measured using high-density electroencephalogram and isolated using source localization.
Changes in power across feedback in the 4-12 Hz and 12-30 Hz bands were reduced within the contralateral motor cortex of essential tremor patients compared to controls. The 12-30 Hz bidirectional connectivity between the parietal and contralateral motor cortex was decreased in essential tremor patients. Worsening of tremor from low to high visual feedback was associated with 4-12 Hz activity in contralateral motor cortex. The greatest separation between groups was found when using the difference of the contralateral motor cortex activity at high and low feedback, rather than either feedback condition alone.
Our findings provide new evidence that tremor in essential tremor is associated with reduced power across feedback in the motor cortex and reduced connectivity between the parietal and motor cortices. Combined with previous work on the cerebellar-thalamo-cortical motor circuit, our findings suggest that the network level disturbances associated with essential tremor extend to the cortico-cortical pathway between the parietal cortex and motor cortex. © 2018 International Parkinson and Movement Disorder Society.
来自特发性震颤功能成像的证据表明，顶叶和运动皮层内的活动可能与在增加视觉反馈时震颤恶化有关。
研究这些区域内的皮层振荡以及这些区域之间的连通性如何与特发性震颤在高视觉反馈下震颤恶化有关。
该研究包括 24 名特发性震颤患者和 17 名对照者。我们在低反馈和高反馈条件下测量了皮质活动和震颤幅度。使用高密度脑电图测量皮质活动，并通过源定位进行分离。
与对照组相比，特发性震颤患者对侧运动皮层在反馈过程中 4-12Hz 和 12-30Hz 频段的功率变化降低。顶叶与对侧运动皮层之间的 12-30Hz 双向连通性在特发性震颤患者中降低。从低反馈到高反馈时震颤恶化与对侧运动皮层的 4-12Hz 活动有关。当使用高和低反馈时对侧运动皮层活动的差异而不是单独使用任何反馈条件时，两组之间的最大差异。
我们的研究结果提供了新的证据，表明特发性震颤的震颤与运动皮层反馈过程中的功率降低以及顶叶和运动皮层之间的连通性降低有关。结合以前对小脑-丘脑-皮层运动回路的研究，我们的研究结果表明，与特发性震颤相关的网络水平紊乱延伸至顶叶和运动皮层之间的皮质-皮质通路。© 2018 国际帕金森和运动障碍协会。
