B(CH)-促进的光氧化还原催化下苯乙烯与烷基 N-羟基邻苯二甲酰亚胺酯和胺的烷基化反应。
Alkylamination of Styrenes with Alkyl N-Hydroxyphthalimide Esters and Amines by B(CH)-Facilitated Photoredox Catalysis.
机构信息
Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle , Nanchang Hangkong University , Nanchang 330063 , China.
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , China.
出版信息
Org Lett. 2018 Nov 2;20(21):6659-6662. doi: 10.1021/acs.orglett.8b02670. Epub 2018 Oct 22.
A new, three-component 1,2-alkylamination of styrenes with alkyl N-hydroxyphthalimide (NHP) esters and amines by Lewis acid and visible-light photoredox cooperative catalysis is described. This reaction employs alkyl NHP esters as general alkylation reagents to accomplish the 1,2-alkylamination of alkenes in high efficiency and with excellent functional groups tolerance, significantly enhancing the synthetic potential of 1,2-alkylaminations of alkenes for accessing complex functionalized amines.
本文描述了一种新的三组分路易斯酸和可见光照化学协同催化的苯乙烯与烷基 N-羟基邻苯二甲酰亚胺（NHP）酯和胺的 1,2-烷基化反应。该反应采用烷基 NHP 酯作为通用烷基化试剂，以高效率和优异的官能团耐受性实现烯烃的 1,2-烷基化，显著提高了烯烃 1,2-烷基化反应合成复杂官能化胺的潜力。
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