Sharma Vishal, Singh Harjeet, Mandavdhare Harshal S
Department of Gastroenterology and General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Infect Disord Drug Targets. 2020;20(2):111-114. doi: 10.2174/1871526518666181022111323.
Abdominal tuberculosis is difficult to diagnose due to low sensitivity of microbiological tests and the low histological yield. Satisfactory response to therapy has long been used a criteria for the diagnosis of abdominal tuberculosis. However, the appropriate definitions of response to therapy in abdominal tuberculosis have remained unclear. Recent evidence suggests that mucosal healing of ulcers at the end of therapy or at two months (early mucosal response) is a helpful criteria of response to therapy. This also helps in exclusion of multidrug resistant tuberculosis and alternative diagnosis like Crohn's disease. Further limited literature suggests the use of some biomarkers like C-reactive protein in the follow-up of patients with peritoneal or intestinal tuberculosis.
由于微生物学检测的敏感性较低以及组织学检查的阳性率较低，腹部结核难以诊断。长期以来，对治疗的满意反应一直被用作腹部结核诊断的标准。然而，腹部结核治疗反应的适当定义仍不明确。最近的证据表明，治疗结束时或两个月时溃疡的黏膜愈合（早期黏膜反应）是治疗反应的一个有用标准。这也有助于排除耐多药结核病和克罗恩病等其他诊断。进一步的有限文献表明，在腹膜或肠道结核患者的随访中可使用一些生物标志物，如C反应蛋白。
