Novas M L, Medina J H, Calvo D, De Robertis E
Eur J Pharmacol. 1987 Mar 17;135(2):243-6. doi: 10.1016/0014-2999(87)90619-4.
Fifteen minutes after the initiation of swimming stress in the rat we observed a 50% increase in the number of [3H]RO 5-4864 binding sites in kidney and a 37% increase in the olfactory bulb, without change in affinity. The binding in heart and cerebral cortex remained unchanged after the stress. These results are discussed in relation to previous work on both the action of an acute stress in central benzodiazepine receptors and the possible modulation of peripheral benzodiazepine receptors of the kidney by adrenocortical hormones.
在大鼠开始游泳应激15分钟后，我们观察到肾脏中[3H]RO 5-4864结合位点的数量增加了50%，嗅球中增加了37%，亲和力没有变化。应激后心脏和大脑皮层中的结合情况保持不变。这些结果结合先前关于急性应激对中枢苯二氮䓬受体的作用以及肾上腺皮质激素对肾脏外周苯二氮䓬受体可能的调节作用的研究进行了讨论。
