From the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
Dermatitis. 2018 Nov/Dec;29(6):339-344. doi: 10.1097/DER.0000000000000413.
The economic burden of cosmetics, such as moisturizers, has been increasing. Despite the high price of some market moisturizers, there have been no studies evaluating the allergenicity of these products.
The aim of this study was to evaluate the potential allergens within moisturizers based on economic value, by analyzing the substances found in moisturizers available online at the largest drugstore chain-CVS Health (CVS Health, Woonsocket, RI).
In this cross-sectional study, ingredients found in 50 expensive and 50 inexpensive moisturizers were matched with sensitizers within the Core Allergen Series published by the American Contact Dermatitis Society and the North American Contact Dermatitis Group. Student t test was used to compare the mean number of allergens present in each group. A χ test or Fisher exact test, where necessary, was used to compare the rates of specific allergen groups between the expensive and inexpensive products.
Twenty-six allergenic substances were present overall in the 100 total products surveyed. The expensive moisturizers averaged significantly more allergens per product (8.28 vs 5.60, P = 0.003) than the inexpensive products.
The sensitizing potential of expensive moisturizers may be higher than that of inexpensive moisturizers. Physicians may counsel cosmetic-induced allergic contact dermatitis (ACD) patients that monetary value is not a suitable proxy for evaluating the risk of ACD.
化妆品（如保湿霜）的经济负担一直在增加。尽管一些市场保湿霜的价格较高，但尚未有研究评估这些产品的变应原性。
本研究旨在通过分析在线上最大的连锁药店 CVS Health（CVS Health，RI）上购买的保湿霜中所含的物质，根据经济价值评估保湿霜中的潜在变应原。
在这项横断面研究中，将 50 种昂贵和 50 种便宜的保湿霜中的成分与美国接触性皮炎学会和北美接触性皮炎组发布的核心变应原系列中的变应原进行匹配。使用学生 t 检验比较每组中存在的变应原数量的平均值。必要时使用 χ²检验或 Fisher 确切检验比较昂贵和便宜产品之间特定变应原组的发生率。
在所调查的 100 种产品中，共有 26 种变应性物质。昂贵的保湿霜平均每款产品的变应原数量明显多于便宜的保湿霜（8.28 比 5.60，P = 0.003）。
昂贵保湿霜的致敏潜力可能高于便宜保湿霜。医生可能会告知因化妆品引起的过敏性接触性皮炎（ACD）患者，金钱价值并不是评估 ACD 风险的合适指标。
