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引入 Papworth 止血检查表后,减少了再次探查和血制品输注。

Reduced re-exploration and blood product transfusion after the introduction of the Papworth haemostasis checklist†.

机构信息

Department of Cardiothoracic Surgery, Royal Papworth Hospital, Cambridge, UK.

出版信息

Eur J Cardiothorac Surg. 2019 Apr 1;55(4):729-736. doi: 10.1093/ejcts/ezy362.

Abstract

OBJECTIVES

Between 2% and 8% of patients return to the theatre for mediastinal bleeding following cardiac surgery. In the majority of patients, a surgical source of bleeding is identified. Both mediastinal bleeding and re-exploration are associated with increased morbidity and mortality and the use of blood products. The aim of this study was to develop a 'haemostasis checklist' with the intention of reducing mediastinal bleeding and re-exploration following cardiac surgery.

METHODS

The Papworth haemostasis checklist was developed with a multidisciplinary collaboration. It consists of 2 components: surgical sites and coagulation status. The checklist is completed at a 'time-out' prior to sternal wire insertion. The analysis compared the outcomes of patients undergoing cardiac surgery in the 1 year before and after implementation. A propensity analysis assessed the impact of re-exploration on outcomes.

RESULTS

Three thousand eight hundred and eleven patients underwent cardiac surgery during the study period. Re-exploration for bleeding was associated with inferior outcomes. Following checklist implementation, there was a significant reduction in the re-exploration rate (3.47% vs 2.08%, P = 0.01) and proportion of patients bleeding >1 l in 12 h (6.1% vs 3.49%, P < 0.001). There was a significant reduction in consumption of blood products saving £102 165 ($134 198). The checklist implementation was associated with reduced intensive care unit length of stay and hospital length of stay, adding to the financial benefit.

CONCLUSIONS

The haemostasis checklist represents a simple intervention which is quick and easy to use but has had a substantial impact on clinical outcomes. We have observed a significant reduction in the mediastinal blood loss, return-to-theatre rate and consumption of blood products, which is associated with a significant clinical and financial benefit.

摘要

目的

心脏手术后,有 2%至 8%的患者因纵隔出血而返回手术室。在大多数患者中,可确定出血的手术来源。纵隔出血和再次探查均与发病率和死亡率增加以及血液制品的使用有关。本研究旨在开发一种“止血检查表”,以期减少心脏手术后的纵隔出血和再次探查。

方法

Papworth 止血检查表是由多学科合作开发的。它由两部分组成:手术部位和凝血状态。检查表在胸骨钢丝插入前的“暂停时间”完成。分析比较了实施前后 1 年内接受心脏手术的患者的结果。倾向分析评估了再次探查对结果的影响。

结果

在研究期间,有 3811 例患者接受了心脏手术。再次探查出血与较差的结果相关。实施检查表后,再次探查率显著降低(3.47%比 2.08%,P=0.01),12 小时内出血>1L 的患者比例也显著降低(6.1%比 3.49%,P<0.001)。血液制品的使用量显著减少,节省了 102165 英镑(134198 美元)。检查表的实施与重症监护病房住院时间和住院时间的缩短有关,这也增加了经济效益。

结论

止血检查表是一种简单的干预措施,快速易用,但对临床结果产生了重大影响。我们观察到纵隔出血量、返回手术室率和血液制品使用量显著减少,这与显著的临床和经济效益相关。

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