Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy , Sichuan University , Chengdu 610041 , China.
Org Lett. 2018 Nov 2;20(21):6701-6704. doi: 10.1021/acs.orglett.8b02779. Epub 2018 Oct 22.
An asymmetric synthetic approach to a tetracyclic framework of the marine-derived alkaloid (+)-sarain A has been developed. The key steps to constructing the congested diazatricycloundecane core include an asymmetric Diels-Alder cycloaddition, an Ireland-Claisen rearrangement, and an intramolecular aziridination/ring-opening sequence.
已开发出一种不对称合成方法，用于构建海洋衍生生物碱 (+)-sarain A 的四环骨架。构建拥挤的氮杂三环十一烷核心的关键步骤包括不对称 Diels-Alder 环加成、Ireland-Claisen 重排和分子内氮丙啶/开环序列。
