1 School of Dentistry, Federal University of Santa Catarina , Florianópolis, Santa Catarina , Brazil.
2 Department of Dentistry, Federal University of Santa Catarina , Florianópolis, Santa Catarina , Brazil.
Dentomaxillofac Radiol. 2019 Mar;48(3):20180112. doi: 10.1259/dmfr.20180112. Epub 2018 Nov 7.
: Determine the prevalence of radiographic findings (RF) on both jaws among patients receiving antiresorptive bone therapy.
: Six electronic databases and partial grey literature were searched. Data was collected based on predetermined criteria. The key features from the included studies were extracted. The MAStARI tool assessed the potential risk of bias (RoB) among the studies, while the GRADE approach determined the level of evidence.
: 29 studies were identified and included in the qualitative analysis, totalling 1133 patients. 27 studies had sufficient data to be included in a series of meta-analysis reporting 12 types of radiographic findings, and were split in two groups based on their study design. G1 comprised descriptive observational studies and G2 analytical cross-sectional studies. Two studies presented a high RoB, 16 had a moderate RoB, and 11 had low RoB. The overall level of evidence identified was very low. The most frequent RF were mixed lytic-sclerotic areas (73.88%), followed by osteolytic changes (66.18%), osteosclerosis (65.75%), cortical bone erosion (50.83%), persisting alveolar socket (45.77%), periodontal ligament (PDL) widening (44.69%), and inferior alveolar canal (IAC) involvement (43.40%). Less frequent, but equally important, were the periosteal reaction (34.27%), lamina dura thickening (32.97%), sequestrum (29.94%), pathologic fracture (20.90%), and density confluence of cortical and cancellous bone (16.61%). 20 patients reported no signs.
: RF prevalence was high and mainly included mixed lytic-sclerotic areas, osteolysis, osteosclerosis, cortical bone erosion, persisting alveolar socket, PDL-widening, IAC-involvement. Due to the very low level of evidence (GRADE) caution should be exercised when considering these findings.
确定接受抗吸收骨治疗的患者在上下颌中出现放射影像学表现（RF）的流行率。
检索了 6 个电子数据库和部分灰色文献。根据预先确定的标准收集数据。从纳入的研究中提取关键特征。MAStARI 工具评估了研究中潜在的偏倚风险（RoB），而 GRADE 方法则确定了证据水平。
确定了 29 项研究并进行了定性分析，共计 1133 名患者。27 项研究有足够的数据纳入一系列报告 12 种放射影像学表现的荟萃分析，并根据其研究设计分为两组。G1 包括描述性观察研究，G2 包括分析性横断面研究。两项研究存在高 RoB，16 项研究存在中 RoB，11 项研究存在低 RoB。确定的总体证据水平非常低。最常见的 RF 是混合溶骨-硬化区域（73.88%），其次是溶骨变化（66.18%）、骨硬化（65.75%）、皮质骨侵蚀（50.83%）、持续牙槽窝（45.77%）、牙周韧带（PDL）增宽（44.69%）和下颌管（IAC）受累（43.40%）。不太常见但同样重要的是骨膜反应（34.27%）、硬骨膜增厚（32.97%）、死骨（29.94%）、病理性骨折（20.90%）和皮质骨和松质骨密度融合（16.61%）。20 名患者报告无迹象。
RF 流行率很高，主要包括混合溶骨-硬化区域、溶骨、骨硬化、皮质骨侵蚀、持续牙槽窝、PDL 增宽、IAC 受累。由于证据水平非常低（GRADE），在考虑这些发现时应谨慎。
