流式细胞术检测晚期生殖细胞肿瘤原发灶的DNA含量。

Flow cytometry derived DNA content of the primary lesions of advanced germ cell tumours.

作者信息

Sledge G W, Eble J N, Roth B J, Wuhrman B P, Einhorn L H

出版信息

Int J Androl. 1987 Feb;10(1):115-20. doi: 10.1111/j.1365-2605.1987.tb00172.x.

DOI:10.1111/j.1365-2605.1987.tb00172.x

Abstract

We currently lack good prognostic indicators for patients with advanced disseminated germ cell tumours (GCT). An analysis of archival tumour samples of forty-nine patients with advanced GCT for flow cytometry derived DNA content suggests an inverse relationship between tumour proliferative activity and patient survival. The great majority of patients with advanced GCT have aneuploid tumour subpopulations. This analysis suggests that the survival of patients with advanced GCT may depend in part on kinetic variables present in the primary tumour.

摘要

目前，我们缺乏针对晚期播散性生殖细胞肿瘤（GCT）患者的良好预后指标。对49例晚期GCT患者的存档肿瘤样本进行流式细胞术DNA含量分析，结果显示肿瘤增殖活性与患者生存率呈负相关。绝大多数晚期GCT患者存在非整倍体肿瘤亚群。该分析表明，晚期GCT患者的生存可能部分取决于原发肿瘤中存在的动力学变量。