Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Oxford, OX3 7FZ, UK.
Biomed J. 2018 Aug;41(4):242-248. doi: 10.1016/j.bj.2018.08.003. Epub 2018 Sep 11.
The influenza virus was instrumental in unravelling critical aspects of the antiviral T lymphocyte mediated immune response. A major finding was the demonstration that CD8 T lymphocytes recognize short viral peptides presented by class I molecules of the major histocompatibility complex. Studies of influenza specific T cells have also led to an understanding of their important role in recovery from influenza virus infection in humans.
流感病毒在揭示抗病毒 T 淋巴细胞介导的免疫反应的关键方面发挥了重要作用。一个主要发现是证明 CD8 T 淋巴细胞识别主要组织相容性复合物 I 类分子呈递的短病毒肽。对流感特异性 T 细胞的研究也使人们了解到它们在人类从流感病毒感染中恢复中的重要作用。
