Renal Division, Department of Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Renal Division, Department of Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kidney Int. 2018 Nov;94(5):849-851. doi: 10.1016/j.kint.2018.07.012.
Progressive cyst expansion in autosomal-dominant polycystic kidney disease has been shown to cause regional hypoxia in cystic and pericystic tissue. This results in up-regulation of hypoxia-inducible transcription factor (HIF) 1α in cyst epithelial cells. However, the functional impact of HIF-1α in cystic kidney disease was unknown. A new study has shown that HIF-1α promotes cyst progression in a mouse model of autosomal-dominant polycystic kidney disease.
常染色体显性遗传多囊肾病中囊肿的进行性扩张被认为会导致囊腔和囊周组织的局部缺氧，从而导致囊上皮细胞中缺氧诱导转录因子 1α（HIF-1α）的上调。然而，HIF-1α 在囊性肾病中的功能影响尚不清楚。一项新的研究表明，HIF-1α 可促进常染色体显性遗传多囊肾病小鼠模型中囊肿的进展。
