氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）对检测有发生间质性肺病（ILD）高风险的肺癌患者的影响。
Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD.
作者信息
Flechsig Paul, Hural Olena, Kreuter Michael, Eichhorn Martin, HEUßEL Gudula, Sachpekidis Christos, Kauczor Hans-Ulrich, Haberkorn Uwe, Heussel Claus Peter, Eichinger Monika
机构信息
Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany.
出版信息
In Vivo. 2018 Nov-Dec;32(6):1457-1462. doi: 10.21873/invivo.11399.
BACKGROUND/AIM: Idiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF.
PATIENTS AND METHODS
Patients with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computer tomography (FDG-PET/CT) results before lobectomy for LC with and without (n=10 each) signs of ILD in initial imaging and after-care CT were retrospectively analyzed. FDG uptake was calculated as the maximum standardized uptake value (SUV) in the lung periphery divided by the SUV of the mediastinal blood pool (rSUV). Regional increase of fibrosis and ground-glass features in lobe-based CT analysis was used as standard reference.
RESULTS
Patients with LC with ILD presented a significantly higher rSUV of 0.57 compared to patients without ILD with rSUV 0.47 (p<0.001).
CONCLUSION
rSUV seems to be a valuable imaging surrogate in predicting patients with LC with increased risk for progressive ILD associated with thoracic surgery.
背景/目的：特发性肺纤维化（IPF）是一种预后较差的间质性肺疾病（ILD）。肺癌（LC）是IPF的常见并发症，在IPF中所有治疗选择都是IPF急性加重的潜在触发因素。
患者与方法
回顾性分析在接受LC肺叶切除术前进行2-脱氧-2-氟-D-葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）检查的患者，初始影像及术后CT检查中有无ILD征象各10例。FDG摄取计算为肺周边最大标准化摄取值（SUV）除以纵隔血池SUV（rSUV）。基于叶的CT分析中纤维化和磨玻璃影的区域增加用作标准参考。
结果
与无ILD的LC患者（rSUV为0.47）相比，有ILD的LC患者的rSUV显著更高，为0.57（p<0.001）。
结论
rSUV似乎是预测接受胸外科手术的LC患者发生进行性ILD风险增加的有价值的影像替代指标。
Zotero 插件