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使用脂肪乳剂疗法治疗犬因摄入拉莫三嗪继发的严重心脏毒性。

The use of intralipid emulsion therapy to treat severe cardiotoxicity secondary to lamotrigine ingestion in a dog.

作者信息

Bellis Tara J, Gibeon Laura

机构信息

Emergency and Critical Care Department BluePearl Veterinary Partners New York New York.

出版信息

Clin Case Rep. 2018 Aug 30;6(10):1982-1988. doi: 10.1002/ccr3.1733. eCollection 2018 Oct.

DOI:10.1002/ccr3.1733
PMID:30349712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6186877/
Abstract

Lamotrigine is a sodium and calcium channel blocker, used to treat seizures in people. Dogs metabolize Lamotrigine to a cardiotoxic metabolite that causes severe, often fatal ventricular arrhythmias. This report documents the successful treatment of refractory Lamotrigine cardiotoxicity in a dog, using intralipid emulsion therapy.

摘要

拉莫三嗪是一种钠通道和钙通道阻滞剂，用于治疗人类癫痫。犬类会将拉莫三嗪代谢为一种心脏毒性代谢物，可导致严重的、通常致命的室性心律失常。本报告记录了使用脂肪乳剂疗法成功治疗一只犬难治性拉莫三嗪心脏毒性的案例。

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Clin Case Rep. 2018 Aug 30;6(10):1982-1988. doi: 10.1002/ccr3.1733. eCollection 2018 Oct.
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本文引用的文献

1
Severe lamotrigine toxicosis in a dog.一只狗的严重拉莫三嗪中毒
Vet Med (Auckl). 2017 Apr 18;8:27-30. doi: 10.2147/VMRR.S131583. eCollection 2017.
2
Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.急性拉莫三嗪过量：已发表的成人和儿科病例系统评价。
Clin Toxicol (Phila). 2018 Feb;56(2):81-89. doi: 10.1080/15563650.2017.1370096. Epub 2017 Sep 1.
3
Safety profile of lamotrigine in overdose.拉莫三嗪过量使用时的安全性概况。
Ther Adv Psychopharmacol. 2016 Dec;6(6):369-381. doi: 10.1177/2045125316656707. Epub 2016 Aug 8.
4
Massive lamotrigine poisoning. A case report.
Brain Dev. 2017 Apr;39(4):349-351. doi: 10.1016/j.braindev.2016.11.003. Epub 2016 Nov 19.
5
A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening.碳酸氢钠用于治疗QRS波增宽的文献综述
J Med Toxicol. 2016 Mar;12(1):121-9. doi: 10.1007/s13181-015-0483-y.
6
Evolving Electrocardiographic Changes in Lamotrigine Overdose: A Case Report and Literature Review.拉莫三嗪过量时不断演变的心电图变化：一例报告及文献综述
Cardiovasc Toxicol. 2015 Oct;15(4):394-8. doi: 10.1007/s12012-014-9300-0.
7
Use of intravenous lipid emulsions for treating certain poisoning cases in small animals.静脉注射脂质乳剂在小动物某些中毒病例治疗中的应用。
Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):251-62, vi. doi: 10.1016/j.cvsm.2011.12.001. Epub 2012 Jan 4.
8
Severe sodium channel blockade and cardiovascular collapse due to a massive lamotrigine overdose.由于大剂量拉莫三嗪过量，严重的钠通道阻断和心血管衰竭。
Clin Toxicol (Phila). 2011 Nov;49(9):854-7. doi: 10.3109/15563650.2011.617307. Epub 2011 Oct 5.
9
Lipid emulsion as rescue therapy in lamotrigine overdose.脂质乳剂作为拉莫三嗪过量的抢救治疗方法。
J Emerg Med. 2012 Jan;42(1):48-51. doi: 10.1016/j.jemermed.2010.11.055. Epub 2011 May 28.