Andersson M, McMichael A, Peterson P A
J Immunol. 1987 Jun 1;138(11):3960-6.
The early region 3 of adenovirus 2 encodes the membrane glycoprotein E19. This protein specifically binds class I transplantation antigens of a variety of species. Concomitant with this interaction the intracellular transport of newly synthesized class I heavy chains is abrogated. At late stages of the virus infection this leads to a notable decrease in the cell surface expression of class I antigens. We have studied how infection with adenovirus 2 influences target cell recognition by alloreactive cytolytic T lymphocytes. We found that the E19 protein-induced reduction of the HLA-B7 cell surface expression led to a greatly reduced lysis of the infected cells. These findings support our hypothesis that the E19 protein has evolved to facilitate the in vivo replication of the virus by reducing the expression of HLA class I antigens.
腺病毒2的早期区域3编码膜糖蛋白E19。该蛋白特异性结合多种物种的I类移植抗原。伴随这种相互作用，新合成的I类重链的细胞内运输被消除。在病毒感染的后期，这导致I类抗原在细胞表面的表达显著降低。我们研究了腺病毒2感染如何影响同种异体反应性细胞毒性T淋巴细胞对靶细胞的识别。我们发现，E19蛋白诱导的HLA - B7细胞表面表达降低导致被感染细胞的裂解大大减少。这些发现支持了我们的假设，即E19蛋白通过降低HLA I类抗原的表达而进化，以促进病毒在体内的复制。
