Mlynarczyk-Bonikowska Beata, Muszyński Jacek, Szymanek-Mjchrzak Ksenia, Ziółowski Bartomiej, Mlynarczyk Graiyna, Malejczyk Magdalena, Majewski Lawomir
Med Dosw Mikrobiol. 2017;69(1):49-54.
Potential role of HPV infection in pathogenesis of colon polyps and cancer remains undetermined. The aim of the study was to investigate the prevalence of DNA of HPV- 6, -11, -16 and -18 in the biopsies from colon polyps.
We investigated the biopsies from 24 patients (23 from colon polyps and I from colon cancer) of Department of Gastroenterology Medical University of Warsaw using Real time PCR HPV-6/11. Real-TM (Sacace Biotechnologies) was performed on termocycler Smart Cycler Dx.
We didn't detect oncogenic HPV16 and HPV18 in any of the investigated specimens, HPV-11 was present in 11 patients including all patients with adenoma tubule-villosum. We detect HPV6 in 5 samples from polyps and 1 from colon cancer.
HPV 6 and HPV 11 could play a role in pathogenesis some colon polyps but the final conclusions demand further investigations. Oncogenic HPV 16 and 18 probably don't play any role in colon polyps pathogenesis.
人乳头瘤病毒（HPV）感染在结肠息肉和癌症发病机制中的潜在作用尚未确定。本研究的目的是调查结肠息肉活检组织中HPV-6、-11、-16和-18的DNA流行情况。
我们使用实时PCR HPV-6/11对华沙医科大学胃肠病学系24例患者（23例来自结肠息肉，1例来自结肠癌）的活检组织进行了研究。在实时定量PCR仪Smart Cycler Dx上进行Real-TM（Sacace生物技术公司）检测。
在任何研究标本中均未检测到致癌性HPV16和HPV18，11例患者中检测到HPV-11，包括所有绒毛管状腺瘤患者。我们在5份息肉样本和1份结肠癌样本中检测到HPV6。
HPV 6和HPV 11可能在某些结肠息肉的发病机制中起作用，但最终结论需要进一步研究。致癌性HPV 16和18可能在结肠息肉发病机制中不起任何作用。
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