Caroon J M, Clark R D, Repke D B, Kluge A F, Strosberg A M, Whiting R L, Okada M D, Hedley L R, Van Antwerp D, Brown C M
J Pharm Sci. 1987 Jan;76(1):32-4. doi: 10.1002/jps.2600760110.
Several 1-acyl-4-[2-(1,4-benzodioxan-2-yl)-2-hydroxy-ethylamino]piperidine s were prepared and a number of the compounds showed antihypertensive activity in the spontaneously hypertensive rat (SHR). This activity was specific for the (2S, 2R) enantiomers. General pharmacological evaluation and ligand binding data on selected compounds indicated a moderate degree of alpha 1- and beta-antagonistic activity. The alpha 1 antagonism was probably not of sufficient magnitude to explain the blood pressure lowering activity in the SHR.
