Antihypertensive 1-acyl-4-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethylamino]pip eridines.
作者信息
Caroon J M, Clark R D, Repke D B, Kluge A F, Strosberg A M, Whiting R L, Okada M D, Hedley L R, Van Antwerp D, Brown C M
出版信息
J Pharm Sci. 1987 Jan;76(1):32-4. doi: 10.1002/jps.2600760110.
PMID:3035169
Abstract
Several 1-acyl-4-[2-(1,4-benzodioxan-2-yl)-2-hydroxy-ethylamino]piperidine s were prepared and a number of the compounds showed antihypertensive activity in the spontaneously hypertensive rat (SHR). This activity was specific for the (2S, 2R) enantiomers. General pharmacological evaluation and ligand binding data on selected compounds indicated a moderate degree of alpha 1- and beta-antagonistic activity. The alpha 1 antagonism was probably not of sufficient magnitude to explain the blood pressure lowering activity in the SHR.
摘要
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