Shlyapnikov D M, Shur P Z, Alekseev V B, Uhabov V M, Novoselov V G, Perevalov A Ya
Med Tr Prom Ekol. 2016(8):6-10.
The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between occupational exposure to noise over 83 dB and hypertension and its predictors - increased activity of serum lipoprotein and homocystein. The studies determined an indicator of the workers' increased sensitivity to arterial hypertension development and to changes in parameters of disordered vascular tone regulation (increased activity of serum lipoprotein and homocystein) under exposure to noise - CT genotype of MTHFR gene. Workers with CT genotype of MTHFR gene, according to epidemiologic analysis, demonstrated increase in relative risk of vascular tone regulation disorders (hypertension predictor). Additional probability ofvascular tone regulation disorders under exposure to noise of 83 dB in sylvinitedressing workers with increased individual sensitivity is estimated at 3%.
本文探讨了钾盐选矿厂工人职业性高血压风险评估结果，并考虑了个体敏感性。流行病学研究证明，职业性接触83分贝以上噪声与高血压及其预测指标——血清脂蛋白和同型半胱氨酸活性增加之间存在相关性。研究确定了工人在噪声暴露下对动脉高血压发展和血管张力调节紊乱参数变化（血清脂蛋白和同型半胱氨酸活性增加）敏感性增加的一个指标——MTHFR基因的CT基因型。根据流行病学分析，MTHFR基因CT基因型的工人表现出血管张力调节紊乱（高血压预测指标）相对风险增加。钾盐选矿厂个体敏感性增加的工人在接触83分贝噪声时血管张力调节紊乱的额外概率估计为3%。
