Liu Dehai, Gao Yaru, Huang Jie, Fu Zhenqian, Huang Wei
Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials , Nanjing Tech University , 30 South Puzhu Road , Nanjing 211816 , China.
Shaanxi Institute of Flexible Electronics (SIFE) , Northwestern Polytechnical University (NPU) , 127 West Youyi Road , Xi'an 710072 , China.
J Org Chem. 2018 Nov 16;83(22):14210-14217. doi: 10.1021/acs.joc.8b02532. Epub 2018 Oct 30.
Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.
通过卡宾催化的烯醛与2-甲基-3-氧代乙酸酯吲哚的氧化形式[4+2]环化反应，已成功开发出咔唑的直接快速构建方法。这种无金属反应具有广泛的底物范围，具有良好的官能团耐受性，在温和条件下进行，并且易于放大规模。
