Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, PR China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China.
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, PR China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China.
Gene. 2019 Feb 5;684:47-52. doi: 10.1016/j.gene.2018.10.045. Epub 2018 Oct 22.
Ikaros, encoded by IKZF1 (Ikaros family zinc finger 1), is an important transcription factor in the control of lymphocyte specification and differentiation. Multiple functions of Ikaros have been exerted in almost all hematopoietic cell types, from stem cells to mature lymphoid and myeloid cells. Moreover, nonhematopoietic cells are also functional targets of Ikaros. Ikaros is essential for normal hematopoiesis, autoimmune and tumor suppression. Ikaros mutations were associated with lymphoblastic cells deficiency, autoimmunity and malignancies development, including hematological malignancies (leukemia) and solid tumors. This review focus on discuss the role of Ikaros in hematological malignancies, solid tumors and autoimmune diseases, and highlight the importance of Ikaros in cancer and immune diseases therapy.
Ikaros，由 IKZF1（Ikaros 家族锌指蛋白 1）编码，是控制淋巴细胞特异性和分化的重要转录因子。Ikaros 的多种功能几乎在所有造血细胞类型中发挥作用，从干细胞到成熟的淋巴样和髓样细胞。此外，非造血细胞也是 Ikaros 的功能靶标。Ikaros 对正常造血、自身免疫和肿瘤抑制至关重要。Ikaros 突变与淋巴母细胞缺陷、自身免疫和恶性肿瘤的发展有关，包括血液系统恶性肿瘤（白血病）和实体肿瘤。本文综述了 Ikaros 在血液系统恶性肿瘤、实体肿瘤和自身免疫性疾病中的作用，并强调了 Ikaros 在癌症和自身免疫性疾病治疗中的重要性。
